Angiogenic response to extracorporeal shock wave treatment in murine skin isografts

Stojadinovic A, Elster E, Anam EA, et al.Angiogenesis. 2008; 11(4):369-380

Alexander Stojadinovic ¹, Eric A Elster, Khairul Anam, Douglas Tadaki, Mihret Amare, Stephen Zins, Thomas A Davis

Affiliations expand

• PMID: 18998221
• DOI: 10.1007/s10456-008-9120-6

Abstract

Skin grafts are commonly utilized and proven effective methods of open wound coverage. Revascularization through neoangiogenesis is a pivotal mechanism for skin graft integration and durability. Extracorporeal shock-wave treatment (ESWT) has been demonstrated to accelerate wound repair; however, its mechanism-of-action is unclear. We investigated the role of ESWT in early revascularization of full-thickness skin isografts in a murine model. Cohorts of mice were euthanized and skin grafts were harvested 6 h, 2, 4, and 7 days post grafting +/- ESWT. 

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