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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
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SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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softwave device with water water blue background

What are the Side Effects of SoftWave Therapy

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

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In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

DIGEST Guidelines for Extracorporeal Shock Wave Therapy

Three-time Super Bowl Champ RandyCross Finds Pain Relief With InnovativeTherapy from SoftWave TRT

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Effective Medical Devices for Treating Patellar Tendonitis 

Effective Medical Devices for Treating Patellar Tendonitis 

Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

LL37 and shock waves

Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Extracorporeal Shock Wave Device for Treatment of Chronic Burns

Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

Mechano-transduction effect of shock waves

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Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Symptomatic treatment of unresponsive wakefulness syndrome with transcranial focused extracorporeal shock waves

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Equine extracorporeal shock wave therapy

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: a single-center, randomized, placebo-controlled clinical trial.

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

The influence of comorbidities – ESWT for chronic soft tissue wounds

Extracorporeal shock wave treatment of capsular fibrosis after mammary augmentation

Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy

Plantar Fasciitis Medical Devices That Relieve Pain

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Prof. M. Kravchik. Focused shockwave therapy in the treatment of the spine. Oxford, UK Non-invasive treatment of herniated discs by focused shock wave therapy

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Evaluation of extracorporeal shock wave therapy for osteoarthritis

Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

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A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Effect of shock waves on macrophages

The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

Shock waves promote spinal cord repair via TLR3

Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis

SoftWave Celebrates Pro Success of Golfer Jake Peacock and Baseball Player Reid Worley, Highlighting Injury Prevention Breakthroughs

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Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

EPAT Therapy for Plantar Fasciitis vs Alternatives

Shockwave Therapy Contraindications- When Not to Use It

Shockwave Therapy Contraindications: When Not to Use It

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

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Best Medical Devices for Treating Carpal Tunnel Syndrome

Best Medical Devices for Treating Carpal Tunnel Syndrome

Shock wave treatment enhances stemness and preserves multipotency

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

Baker’s Cysts

Best Medical Devices for Treating Baker’s Cysts

Purple Heart Recipient Uses Innovative Technology to Treat Fellow Veterans

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Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

ESWT for resident stress fractures in athletes.

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

TRT SoftWaves® – a new regenerative therapy for paraplegia

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Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

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Best Physical Therapy Devices Clinics Must Have

Best Physical Therapy Devices Clinics Must Have

EPAT Therapy Costs for Patients & Practices

Latest Basic Research Abstracts

Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Influence of extracorporeal shock wave therapy (ESWT) on bone turnover markers in organisms with normal and low bone mineral density during fracture healing: a randomized clinical trial

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Low-Intensity Shockwave Therapy May Be Beneficial for Women With Provoked Vestibulodynia

​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Knee Pain Relief through Advanced Shockwave Therapy

SoftWave: Leading the Way in Knee Pain Relief through Advanced Shockwave Therapy

Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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Do Gymna Shockmaster Machines Work for Patients?

Do Gymna Shockmaster Machines Work for Patients?

The effect of shock waves on in vitro cartilage development in silk scaffolds

Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag​)

TISSUE REGENERATION TECHNOLOGIES, LLC Establishment Registration & Device Listing

Low Intensity Shockwave Therapy vs High Intensity: Which Works Best?

Shockwave therapy in stress fractures

Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Neuropathy

Shockwave Therapy for Neuropathy

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

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Is surgery the only option for bone-on-bone?

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MTS Spark WaveTM Technology and its mechanism of action in wound management

Shock wave therapy for systemic sclerosis

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Pilot Trial, First Report Worldwide for Unfocused SoftWave® Therapy (uESWT) for the Treatment of Testicles to Improve Testicular Size and Function

Spark Wave® Therapy Improves Full Thickness Skin Defects

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Angiogenic response upon shock wave treatment of the ischaemic muscle

Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

SoftWave Tissue Regeneration Technologies Receives FDA Clearance for Blood Circulation Increase, Minor Aches and Pains Relief and Connective Tissue Activation

​Prospective randomized phase II trial of accelerated reepithelialization

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

ISSWSH Abstract

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: A single-center, randomized, placebo-controlled clinical trial

Plantar Fasciitis Medical Devices That Relieve Pain

Does Dermapace Work for Patients?

The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

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COVID-19 pneumonia: different respiratory treatment for different phenotypes?

Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

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Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

Zimmer Shockwave Therapy: Cost, Efficacy, and Alternatives

Using acoustic therapy to prevent opioid addiction.

​The biologic effects of SoftWaves and rationale for spine and brain therapy

Reduce Inflammation Naturally With Shockwave Therapy

7 Red Flags That Signal a Risky Shockwave Device

7 Red Flags That Signal a Risky Shockwave Device

What Is Pneumatic Shockwave Therapy?

What Is Pneumatic Shockwave Therapy?

Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

The Role of the Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Radical Prostatectomy: A Randomized Clinical Trial

Project: SoftWaves to prevent opioid addiction and to help addicts in their recovery.

Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

SoftWave: Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

Test12343

Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

Doctor Uses Shockwave Therapy to Heal Nearly Severed Foot

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Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

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Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

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Sound Frequency Healing: The Spark of Life

Linear Shockwave Therapy in Clinical Practice- Evidence and Mechanisms

Linear Shockwave Therapy Mechanisms and Efficacy Explained

Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Analysis of treatment protocols: application of ESWT for wound healing disorders

Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat—Systematic review

Exploring Alternatives to Pain Treatment: Your Path to Natural Relief

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Regenerative Restorative Care Treatments Post Knee Surgery

Regenerative Restorative Care Treatments Post Knee Surgery

Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Shockwave Therapy for the Treatment of Cancer

Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Comparing Shockwave Therapy Machine Costs

Shockwave + Biologic Regeneration: Two Paths to Healing, One Goal

Shockwave Therapy for Calcific Tendonitis

SoftWave Therapy® Represents a Valuable Addition in the Treatment of Hard-to-Heal Wounds

Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Best Medical Devices for Treating Patellar Tendinitis

Best Medical Devices for Treating Patellar Tendinitis

Shock wave treatment after hindlimb ischemia results in increased perfusion and M2 macrophage presence

Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Extracorporeal shock waves, a new non-surgical method to treat severe burns

Veterinary wound care case study

Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

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Best Noninvasive Options for Regenerative Back Treatment Without Injections

Best Options for Regenerative Back Treatment Without Injections

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Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo

Treatment for osteonecrosis of the femoral head

Optimization of screw fixation in rat bone with extracorporeal shock waves

Shockwave Therapy: Does it Hurt?

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Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

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Top Surgeon: SoftWave ‘a superior way to make tissue want to heal’

Biological Principles – Mechanotransduction

Extracorporeal Magnetic Transduction Therapy Explained

Extracorporeal Magnetic Transduction Therapy Explained

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease.

In vitro extracorporeal shock wave treatment has beneficial effects on rat Schwann cell isolation and culture

OmniWave Shockwave Therapy- Efficacy & Alternatives Explained

OmniWave Shockwave Therapy: Efficacy & Alternatives Explained

Morton's Neuroma

Effective Medical Devices for Treating Morton’s Neuroma

ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration

How Shockwave Therapy Breaks Down Scar Tissue

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

The Roll of Spark Waves in the Management of Chronic Wounds.

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Case Study 1 shows an 80-year old female patient who developed a large infected decubitus ulcer from a lengthy stay in a hospital bed following a knee operation.

Acoustic wave therapy for cellulite, body shaping and fat reduction.

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

ESWT for retracting scars of the hand

Unfocused extracorporeal shock waves induce anabolic effects in rat bone

Shock wave treatment for in vitro engineering applications

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

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2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Best Shockwave Machine for Providers

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Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite e A current metaanalysis​ -(Plastic, Hand and Burn Surgery, University of Schlewig Holstein, Lubeck, Germany​)

A randomized, controlled clinical study to investigate the safety and efficacy of acoustic wave therapy in body contouring

Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

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Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy

Erectile Dysfunction and the Shocking Truth: Is Shockwave Therapy Effective

Treatment of scaphoid waist nonunion

Erectile Dysfunction before and after results under ultrasound

Zapping chronic tendon pain

Can cellulite be treated with low-energy extracorporeal shock wave therapy?

Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Non‑surgical Regenerative Treatments Integrating with PT

Non‑surgical Regenerative Treatments Integrating with PT

Chattanooga Intelect Shockwave Machine- Evidence, Mechanisms, and Clinical Context

Chattanooga Intelect Shockwave Machine: Efficacy & Alternatives

Treatment of stress urinary incontinence

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Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Regenerative Therapies for Hip Pain and Tendinopathy

Regenerative Therapies for Hip Pain and Tendinopathy

Extracorporeal Shock Wave Therapy: Current Evidence

Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines Compared

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Ultrasound Based Brain Stimulation

What Is HydroWave Therapy? Mechanism, Applications, and Clinical Context

What Is HydroWave Therapy? How It Works, Clinical Uses, and Evidence

Tissue Activation and Regeneration in Sports Medicine and Bone Pathologies

International Society for Medical Shockwave Treatment- ESWT BASIC PHYSICAL PRINCIPLES

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses. – PubMed – NCBI

Natural Remedies for Tendonitis

Natural Remedies for Tendonitis

Sports medicine practitioners embrace benefits of extracorporeal shock wave therapy

Dr Irwin Goldstein Dinner Presentation – Nashville

Heart Regeneration becomes Reality!

Technology Assessment “Wound Care” dermagold100

MSC-exosome: A novel cell-free therapy for cutaneous regeneration

Extracorporeal shock wave therapy: clinical applications and regulation

SoftWave vs Shockwave Technology Explained 

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Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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