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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
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SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Spark Wave® Therapy Ameliorates Urinary Incontinence

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves

Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shock wave therapy device

Principles of Shock Wave Therapy

The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy

Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Molecular changes in diabetics foot ulcers

How Does Shockwave Therapy Work?

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

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Shockwave Therapy: Does it Hurt?

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Using acoustic therapy to prevent opioid addiction.

Reduce Inflammation Naturally With Shockwave Therapy

Extracorporeal Shock Wave Device for Treatment of Chronic Wounds

Low-Intensity Shockwave Therapy May Be Beneficial for Women With Provoked Vestibulodynia

Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite e A current metaanalysis​ -(Plastic, Hand and Burn Surgery, University of Schlewig Holstein, Lubeck, Germany​)

Effects of Shock Waves on Expression of IL-6, IL-8, MCP-1, and TNF- alpha Expression by Human Periodontal Ligament Fibroblasts: An In Vitro Study

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

The Effect of Different Doses of Extracorporeal Shock Waves on Experimental Model Mandibular Distraction

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis​

Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Extracorporeal shockwave therapy induces alveolar bone regeneration

Impact of Extracorporeal Shock Wave Therapy (ESWT) on Orthodontic Tooth Movement – A Randomized Clinical Trial

Extracorporeal shock wave therapy surpresses the early proinflammatory immune response to a severe cutaneous burn injury

Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

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Pilot Trial, First Report Worldwide for Unfocused SoftWave® Therapy (uESWT) for the Treatment of Testicles to Improve Testicular Size and Function

Treatment of scaphoid waist nonunion

Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

Pulsewave Therapy- Mechanism of Action and Clinical Indications

Pulsewave Therapy Explained: Mechanism of Action and Clinical Indications

Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Piezowave Therapy Efficacy & Alternatives Explained

Piezowave Therapy Efficacy & Alternatives Explained

Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian men

Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

Adhesive Capsulitis Management with Advanced Shockwave Therapy

SoftWave: Empowering Adhesive Capsulitis Management with Advanced Shockwave Therapy

Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Analysis of treatment protocols: application of ESWT for wound healing disorders

Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment

Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

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OmniWave Shockwave Therapy- Efficacy & Alternatives Explained

OmniWave Shockwave Therapy: Efficacy & Alternatives Explained

Plantar Fasciitis Medical Devices That Relieve Pain

Does Dermapace Work for Patients?

Minimally invasive treatment of Peyronie’s disease: evidence-based progress

Shockwave Therapy for Achilles Tendonitis

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What Is Pulse Wave Therapy & Does It Work for Patients?

What Is Pulse Wave Therapy & Does It Work for Patients?

Veterinary wound care case study

Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

How Shockwave Therapy Compares to Cortisone Injections

How Shockwave Therapy Compares to Cortisone Injections

In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

International Society for Medical Shockwave Treatment- ESWT BASIC PHYSICAL PRINCIPLES

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Effects of Extracorporeal Shockwave Therapy on Patients with Chronic Low Back Pain and Their Dynamic Balance Ability

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Mechano-transduction effect of shock waves

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Sports medicine practitioners embrace benefits of extracorporeal shock wave therapy

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Shockwave Therapy for the Treatment of Cancer

Shock wave treatment of muscle stem cells – a new implementation for regeneration

Effective Medical Devices for Treating Patellar Tendonitis 

Effective Medical Devices for Treating Patellar Tendonitis 

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

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​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Best Physical Therapy Devices Clinics Must Have

Best Physical Therapy Devices Clinics Must Have

Extracorporeal Shockwave Therapy for Arthritis Treatment

Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Dermapace Machines- Cost, Efficacy, & Alternatives

Dermapace Machines: Cost, Efficacy, & Alternatives

Plantar Fasciitis Medical Devices That Relieve Pain

Plantar Fasciitis Medical Devices That Relieve Pain

Elucidating the molecular mechanisms underlying cardiac shock wave therapy

Non-Surgical Alternatives for Degenerative Disc Disease Treatment

Non-Surgical Treatment Options for Degenerative Disc Disease

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Case Study 1 shows an 80-year old female patient who developed a large infected decubitus ulcer from a lengthy stay in a hospital bed following a knee operation.

Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

ISSWSH Abstract

Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Assessment of IL-1Beta and VEGF Concentration in Rat Model During Orthodontic Tooth Movement and Extracorporeal Shock Wave Therapy

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptoms in a first-in-man trial

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Cellulite and Focused Extracorporeal Shockwave Therapy for Non-Invasive Body Contouring: A Randomized Trial

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

The link between shockwaves and innate immunity – the main working mechanism?

Low–Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Is surgery the only option for bone-on-bone?

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ESWT for retracting scars of the hand

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

In vitro characterization and simulation of shockwaves by optical phase contrast imaging, computational modeling and acoustic measurement.

Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Exploring Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

The influence of comorbidities – ESWT for chronic soft tissue wounds

Gainswave Machines: Cost, Efficacy, & Alternatives

Gainswave Machines: Cost, Efficacy, & Alternatives

Alteration Of Inflammatory Response By Shock Wave Therapy Leads To Reduced Calcification Of Decellularized Aortic Xenografts In Mice.

Analysis of extracorporeal shock wave therapy for Peyronie’s disease

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Extracorporeal Shock Wave Therapy: Current Evidence

MTS Spark WavesTM – successfully treating indispositions of the musculoskeletal system

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

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Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

Radial Extracorporeal Shock Wave Therapy to Support Breathing In Case of Coronavirus Disease 2019 (COVID-19): A Case Report

SoftWave on Elbow

Why Chiropractors Choose Shockwave Therapy

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

​Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease

Shock waves promote spinal cord repair via TLR32

Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Alternative Treatment using Shockwave for Erectile Dysfunction

MTS Science White Paper – Softwave – Pain Therapy

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial

Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Three-Time Super Bowl Champion Randy Cross Discovers Pain Relief with SoftWave Therapy

Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

Softwave application on hand

Healing at the Edge of the World: How Dr. Paul Kratka Brings SoftWave to the South Pacific

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

Angiogenic response upon shock wave treatment of the ischaemic muscle

Acoustic wave therapy for cellulite, body shaping and fat reduction.

Sound Frequency Healing: The Spark of Life

EPAT Shockwave Therapy Efficacy & Alternatives Explained

EPAT Shockwave Therapy Efficacy & Alternatives Explained

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Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats

Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

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Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

Effective Medical Devices for Treating Uterine Fibroids

Effective Medical Devices for Treating Uterine Fibroids

Natural Remedies for Tendonitis

Shockwave treatment enhances cell proliferation and improves wound healing

Set up Instructions

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Extracorporeal shock wave therapy relieved pain in patients with coccydynia: a report of two cases

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TRT SoftWaves® – a new regenerative therapy for paraplegia

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​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures

SoftWave Tissue Regeneration Technologies Receives FDA Clearance for Blood Circulation Increase, Minor Aches and Pains Relief and Connective Tissue Activation

Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

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Shock Waves Reach Dental Implantology (Spanish)

Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

EPAT Therapy for Plantar Fasciitis vs Alternatives

IVSWT Water Bath V2.0 Manual

EPAT Therapy Side Effects & Contraindications

Shockwave therapy in stress fractures

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

Better lithotripsy on the horizon: an interview with James E. Lingeman, MD.

Top Surgeon: SoftWave ‘a superior way to make tissue want to heal’

Effects of Low-Energy Shock Waves on Oral Bacteria

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A randomized, controlled clinical study to investigate the safety and efficacy of acoustic wave therapy in body contouring

​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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10 Natural Ways to Find Pain Relief

Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and aging

Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis

Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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Peripheral Nerve Regeneration

​Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

Biological Principles – Mechanotransduction

Acoustic Field of a Ballistic Shock Wave Therapy Device

Using Sound to Battle Opioid Crisis

Extracorporal SoftWave Treatment to Improve Nerve Regeneration

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The Assessment of New Bone Formation Induced by Unfocused Extracorporeal Shock Wave Therapy Applied on Pre-Surgical Phase of Distraction Osteogenesis

Shockwave Therapy for Plantar Fasciitis

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial

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Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

Focused vs Radial Shockwave Therapy Machines Explained 

Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

Shock waves induce angiogenesis via exosome release

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Extracorporeal shockwave treatment for chronic diabetic foot ulcers

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Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

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Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Best Shockwave Machine for Providers

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

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What Is Pneumatic Shockwave Therapy?

What Is Pneumatic Shockwave Therapy?

Shock wave treatment for in vitro engineering applications

Zimmer Shockwave Therapy: Cost, Efficacy, and Alternatives

Technology Assessment “Wound Care” dermagold100

Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

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opioids united states

FDA Tightens Opioid Warning Labels: Here’s the Non-Invasive Alternative Changing Pain Care

Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

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Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Can You Use a Shockwave Therapy Machine at Home?

Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review

Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

SoftWave: Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

low intensity softwave in use on arm on a table

What is Li-ESWT & How Does It Work?

MTS Spark WaveTM Technology and its mechanism of action in wound management

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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