SoftWave Research

Newest Research

Unfocused Low Intensity Extracorporeal Shock Wave Therapy, Li-ESWT, for Nocturia and Erectile Dysfunction

Sharpe MD, Georgia Urology, Atlanta, USA21th ISMST Congress in Beijing, ChinaAbstract P45 Click here to...
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Doubts over heart stem-cell therapy

The cells are then injected back into the patient, to help repair damaged tissue. Original...
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Successful treatment of nonunions with orthogold280

A pseudarthrosis is defined as a non healing fracture from which a false joint develops....
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Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

Since December, 2019, an outbreak of pneumonia caused by a novel coronavirus (SARS-CoV-2) has raised...
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Penile low intensity shock wave therapy for PDE5i non responders: A prospective, randomized, placebo-controlled study

Fundació Puigvert, Barcelona, Spain European Congress of Andrology, Rotterdam, Netherlands Click here to read more.
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The Concept of Spark Wave Therapy (Swt) Assisted Penile Augmentation

Dr. Mirza Niaz Zaman, Kharkiv National Medical University, UkraineJSexMed. May, 2017; e329–e3302016 Click here to read...
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Principles of Shock Wave Therapy

John A. Ogden, MD; Anna Tóth-Kischkat, PhD; and Reiner Schultheiss, PhD Click here to read...
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Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading...
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Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment: A Systematic Review of the Literature

Robert Dymarek, PhD, PT; Tomasz Halski, PhD, PT; Kuba Ptaszkowski, PhD, PT; Lucyna Slupska, PhD,...
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Can cellulite be treated with low-energy extracorporeal shock wave therapy?

The present study investigates the effects of low-energy defocused extracorporeal generated shock waves on collagen...
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ESWT for resident stress fractures in athletes.

Stress fractures are major concerns with athletes. It is sometimes difficult to repair, resulting in...
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Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Department of Rehabilitation Medicine, Nan Lou of Chinese PLA General Hospital, Beijing, China – This study...
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Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

Accelerated tooth movement has been a topic of interest for orthodontic research recently. Surgically facilitated...
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Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

This study determined the effect of electrohydraulic extracorporeal shockwave therapy (ESWT) on the healing of...
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Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Cyrill Slezak Beijing, May 24TH, 2019 Click here to read more.
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Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Pishchalnikov et al.Journal of Endourology / Endourological Society, 27(5), 631–9. https://doi.org/10.1089/end.2012.0611. Click here to read more.
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Exclusive Distribution Agreement With Cynosure – Aesthetics and Sexual Health Markets

Exclusive agreement to supply Cynosure LLC, a global leader in medical aesthetics, with its patented...
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Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Erectile dysfunction is highly prevalent in type II diabetes mellitus.Low intensity extracorporeal shock wave therapy...
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Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

Extracorporeal shock wave therapy has been used in various clinical conditions as a result of...
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Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis

Louise Helen Hitchman, Joshua P. Totty, Ali Raza, Paris Cai, George E. Smith, Daniel Carradice,...
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Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

PubMed (Urology Department, Sheba Medical Center, Ramat-Gan, Israel; Ruth and Bruce Rappaport Faculty of Medicine,...
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Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Holfeld et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

A systematic review and meta-analysis of preclinical studies – Limited regeneration after nerve injury often leads...
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miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous...
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Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

(Yousef Marwan, • Bashar Dahrab • Ali Esmaeel • Samir Abdulrazik Ibrahim • Jassim Al-Failakawi)...
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ESWT in skin & aesthetic indications

ESWT in skin graft epithelialization 3 days faster healing. Click here to read more.
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OrthoGold 100TM

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Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It...
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Shockwave Therapy: Does it Hurt?

At SoftWave we promote healing using shockwave therapy. SoftWave strives to make patients’ lives easier...
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​Extracorporeal shock wave therapy in periodontics: A new paradigm

The quest for exploring new frontiers in the field of medical science for efficient and...
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Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shock wave therapy device

Extracorporeal shock wave therapy (ESWT) uses acoustic pulses to treat certain musculoskeletal disorders. In this...
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Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

MTS Science 2016. Urogenital indications such as painful penile angulation, erection problems and / or chronic...
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FDA Devices and Indications

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Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Hausner t. et al.Experimental Neurology, 236(2), 363–370. https://doi.org/10.1016/j.expneurol.2012.04.019. Click here to read more.
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The influence of comorbidities – ESWT for chronic soft tissue wounds

Department of Surgery, Austrian Armed Forces Hospital-Vienna, Vienna, Austria;  AUVA Trauma Center Meidling, Vienna, Austria; ...
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Technology Assessment “Wound Care” dermagold100

MTS-Science – ​Acute wounds are caused exogenously by traumatic (e.g. mechanical, chemical, thermical) or iatrogenic (e.g. surgical)...
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Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but...
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Extracorporeal Shockwave Therapy Versus Ultrasound Therapy for Plantar Fasciitis

Systematic Review and Meta-Analysis – Objective To compare the outcomes of Extracorporeal Shockwave Therapy (ESWT) versus...
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Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping and localized fat

Systematic review. – Extracorporeal Shockwave Therapy – ESWT has had a wide use in rehabilitation, and...
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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

Extracorporeal shock wave treatment has been used successfully for the treatment of avascular necrosis of...
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Physical Rehabilitation Using Shockwave Therapy

Injuries can have a serious impact on lifestyle and health, which means that physical rehabilitation...
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ISSWSH Abstract

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Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis

Van der Jagt et al.Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society,...
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A randomized, controlled clinical study to investigate the safety and efficacy of acoustic wave therapy in body contouring

The objective of this study was to determine the safety and efficacy of noninvasive lipolysis of excess adiposities overlying the lateral...
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Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy

Extracorporeal shockwave therapy (ESWT) is used in a number of indications in the medical field....
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Effectiveness of Extracorporeal Shock Wave Lithotripsy to treat Dystrophic Calcinosis Cutis

Delgado-Marquez et al.Actas Dermosifiliogr. 2015 Mar;106(2):140-3. doi: 10.1016/j.ad.2014.06.006.  Click here to read more.
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Effects of ESWT on glycosaminoglycan expression during bone healing

Several cases of delayed bone consolidation have been treated with extracorporeal shock wave therapy (ESWT) to improve bone...
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Analysis of treatment protocols: application of ESWT for wound healing disorders

Shock waves are high-energy acoustic waves characterized by an initial rise of high pressure within...
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Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Dr. Slezak et al., Department of Physics Utah Valley University Orem, USA21th ISMST Congress in...
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Efficacy of Unfocused Medium-Intensity Extracorporeal Shock Wave Therapy (MI-ESWT) for Plantar Fasciitis

Extracorporeal shock wave therapy (ESWT) is a promising treatment for plantar fasciitis (PF), however, treatment...
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In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

Journal of Sexual Medicine (Guiting Lin MD PhD, Amanda B. Reed-Maldonado MD, Bohan Wang MD,...
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Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

Elliot B. Lander, MD, Mark H. Berman, MD, Jackie R. See, MD – This pilot study...
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​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Ligament-to-bone and tendon-to-bone interfaces (entheses, osteotendinous junctions [OTJs]) serve to dissipate stress between soft tissue...
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Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats

We hypothesized that combined treatment with extracorporeal shock wave and bone marrow-derived endothelial progenitor cells...
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Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular...
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A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

Alessandro Palmieri, Ciro Imbimbo, Nicola Longo, Ferdinando Fusco, Paolo Verze, Francesco Mangiapia, Massimiliano Creta ,...
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The Biologic Effects of SoftWaves™and Rationale for Spine and Brain Therapy

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

(Dr Irwin Goldstein MD) Analogy to blood flow imparting physical forces – shear stress – onto...
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SoftWave Tissue Regeneration Technologies Receives FDA Clearance for Blood Circulation Increase, Minor Aches and Pains Relief and Connective Tissue Activation

ATLANTA, May 19, 2021 (Newswire) – SoftWave Tissue Regeneration Technologies patented extracorporeal shock wave device called...
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Angiogenic response to extracorporeal shock wave treatment in murine skin isografts

Stojadinovic A, Elster E, Anam EA, et al.Angiogenesis. 2008; 11(4):369-380 Click here to read more.
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Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

The respiratory system (i.e., oral-nasal-laryngeal tract, bronchus, trachea, and alveolar sacs in the lungs) is...
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Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

Graber et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

Research Institute of Environmental Medicine at Heinrich-Heine University, D-40021 Duesseldorf,Germany In vivo measurements in 26...
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Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly...
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Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

This RCT investigated the effect of non-invasive extracorporeal shockwaves on tooth mobility in orthodontic patients...
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Effects of Shock Waves on Expression of IL-6, IL-8, MCP-1, and TNF- alpha Expression by Human Periodontal Ligament Fibroblasts: An In Vitro Study

Extracorporeal shock wave therapy (ESWT) can modulate cell behavior through mechanical information transduction. Human periodontal...
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Shockwave Therapy for the Treatment of Cancer

Breast cancer is characterized by rapid aberrant growth of tissue in the mammary glands. The speed...
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Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Megan BruzanMegan The low-energy extracorporal shockwave is a scientifically approved method to activate respectively increase...
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Angiogenic response upon shock wave treatment of the ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Extracorporeal shockwave therapy versus exercise program in patients with low back pain: short-term results of a randomised controlled trial.

(Notarnicola, Maccagnano, Gallone, Mastromauro, Rifino, Pesce, Covelli , Moretti B) The physiotherapy treatment of low...
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Biological mechanism of shockwave in bone

Shockwave is a rapid, short duration acoustic wave that carries energy and can propagate through...
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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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Comprehensive Urology to Utilize New Shockwave Therapy Device: PulseWave

PRESS RELEASE PR Newswire 2018 – Comprehensive Urology Medical Group, one of the nation’s leading...
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Heart Regeneration becomes Reality!

Regeneration of infarcted heart muscle remained a dream of modern medicine despite of comprehensive research...
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Mesenchymal stem cells: Myths and reality

Mesenchymal stem cells (MSCs; also called mesenchymal stromal cells) have received much attention during the...
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Set up Instructions

Video for setting up the device, inserting the applicator and water cartridge, and how to...
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Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

Patients with systemic sclerosis (SSc) often display Raynaud’s phenomenon and digital skin ulcers. As these...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease.

Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in...
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Effects of Low-Energy Shock Waves on Oral Bacteria

The objective of the present study was to determine any antibacterial effect of ESWT on...
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Influence of medical shock waves on healthy muscle tissue

Competitive sport requires each athlete to be at peak performance at all times. This is...
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Shock wave therapy alone has no impact on cancer growth

Cancer remains one of the leading causes of morbidity and mortality throughout the world. Several...
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Softwave® Tissue Regeneration Technologies Announces Landmark Trial for Acute Traumatic Spinal Cord Injuries

SoftWave® Tissue Regeneration Technologies, a disruptive bio-medical device company, announces the beginning of a trial...
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UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Platelet-rich plasma (PRP) and extracorporeal shockwave therapy (ESWT) are both used for the treatment of...
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Case Series of Weekly Low Intensity Shockwave Therapy for Erectile Dysfunction

Shoskes et al., Cleveland Clinic, United States 20th ISMST Congress in San Sebastian, Spain Abstract...
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ESWT minimizes ischemic tissue necrosis…

Rainer Mittermayr, MD, Joachim Hartinger, Vlado Antonic, MS, Alexandra Meinl, PhD, Sabine Pfeifer, Alexander Stojadinovic,...
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Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

We prospectively studied extracorporeal shock wave therapy (ESWT) for calcific tendinitis of the shoulder in...
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Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Nägele et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

van der Jagt OP, Schaden W, van Schie H et al.Orthopaedic Research Society. 2008; Poster No....
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Low–Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

National Institutes of Health (Xin Zhang, James D. Krier, Carolina Amador Carrascal, James F. Greenleaf, Behzad...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shock wave treatment for in vitro engineering applications

Weihs et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although...
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Spark Wave® Therapy – a New Method for Peripheral Nerve Regeneration

(MTS Science) – Peripheral nerve injuries affect millions of people every year. After trauma or surgery, patients...
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Cellular mechanotransduction: putting all the pieces together again

Vascular Biology Program, Departments of Pathology and Surgery, Harvard Medical School and Children’s Hospital, Boston,...
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​Antibacterial effects of extracorporeal shock waves

Klinik und Poliklinik für Orthopädie und Sportorthopädie der Technischen Universität München, München, Germany; and  Institut...
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MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)

Cellulite is a multifactorial condition that is present in 80-90 % of post-pubertal women, commonly found...
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Alteration Of Inflammatory Response By Shock Wave Therapy Leads To Reduced Calcification Of Decellularized Aortic Xenografts In Mice.

Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading...
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Extracorporeal Shock Wave Therapy: Current Evidence

The aim of this article is to provide a concise review of the basic science...
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​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

In this prospective design study the effects of low-energy partially focusedextracorporeal generated shock waves (ESW)...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Enhancement of flap survival through extracorporeal shock wave treatment (ESWT) is a promising new technique;...
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Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model

Introduction—Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from...
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Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

Mesenchymal stem cells (MSC) possess the distinctive feature of homing in on and engrafting into...
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Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

(​Wei Wei, Hua-yu Tang, Yu-zhi Li, Tian-shu Wang) – : Previous clinical trials have reported that...
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Cleveland Clinic – Low Intensity Shockwaves In Urology

Cleveland Clinic Daniel Shoskes, MD – As urologists, we have decades of experience with extracorporeal shockwave lithotripsy for...
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The Applied Mechanical Vibration as Extracorporeal Shock Wave

Maria Cristina D’Agostino, Simona Maria Carmignano, and Andrea Saggini Click here to read more.
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Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Falkensammer et al.Clin Oral Investig. 2014 Dec;18(9):2187-92. doi: 10.1007/s00784-014-1199-0.  Click here to read more.
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Shockwave therapy in stress fractures

Stress fractures are common painful conditions in athletes, usually associated to biomechanical overloads. Low risk stress...
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Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Lobenwein et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Zimpfer D, Aharinejad S, Holfeld J, et al.J Thorac Cardiovasc Surg. 2009; 137(4):963-970 Click here to...
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Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

For almost 30 years, extracorporeal shock wave therapy has been clinically implemented as an effective...
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Shock wave therapy enhances neuronal sprouting and improves neuronal survival

An et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Shock wave therapy for systemic sclerosis

We studied the effects of ESWT in 8 SSc female patients who received 4 consecutive...
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Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy

Christian Ottomann, MD,∗ Alexander Stojadinovic, MD, FACS, Philip T. Lavin, PhD, Francis H. Gannon, MD,...
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Shockwave Therapy Of The Heart​

Ischemic heart disease represents a collective term for a continuous disease pathophysiology, ranging from acute...
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Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Holfeld J., Zimpfer D., Stojadinvic A., et al.J Tissue Eng Regen Med.  Click here to...
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Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease – A new navigated focal brain therapy

Ultrasound-based brain stimulation techniques offer an exciting potential to modulate the human brain in a...
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Spark Wave® Therapy Improves Cardiac Function

Ischemic heart disease remains the leading cause of mortality (12.7%) worldwide, causing more than 7...
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Impact of Extracorporeal Shock Wave Therapy (ESWT) on Orthodontic Tooth Movement – A Randomized Clinical Trial

This randomized clinical trial investigated the effect of extracorporeal shock waves on the amount of...
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Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Zins et al.Angiogenesis, 13(4), 293–304. https://doi.org/10.1007/s10456-010-9186-9. Abstract Impaired wound healing is a persistent clinical problem which...
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Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model

To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress...
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Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury

(Swiss Paraplegic Centre Nottwil) – Spasticity is the most problematic self-reported secondary medical problem in patients...
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Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

Periodontal inflammation with alveolar bone resorption is a hallmark of periodontitis. We hypothesized that extracorporeal...
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The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Fuchs et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Scientific Reports – Gene transfection by shock waves

Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids...
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The Physics of Shock Wave Lithotripsy

Shock wave lithotripsy (SWL) was introduced in the 1980s for the treatment of urinary stones...
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Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures

Introduction: As of now, the role of extracorporeal shockwave therapy (ESWT) in the treatment of...
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Current concepts of shockwave therapy in stress fractures

Stress fractures are common painful conditions in athletes, usually associated to biomechanical overloads. Low risk...
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Assessment of IL-1Beta and VEGF Concentration in Rat Model During Orthodontic Tooth Movement and Extracorporeal Shock Wave Therapy

This study aimed to investigate PDL’s cytokine concentration fluctuations after induction of orthodontic force with...
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Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

A phase III, randomized, double blind controlled with placebo study – (MTS-Science) – Chronic Prostatitis/ Chronic...
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Shock Waves Reach Dental Implantology (Spanish)

Lithotripsy or Shock Wave Therapy is proving to be an effective non-invasive treatment to regenerate...
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The Roll of Spark Waves in the Management of Chronic Wounds.

Antibiotic-resistant bacterial colonies often produce biofilms (a defensive mechanism that creates a physical protective barrier...
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​Exosomes and Cardiovascular Protection

Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called...
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Limited shock wave therapy vs sham treatment in men with Peyronie’s disease: results of a prospective randomized controlled double-blind trial

Sudhanshu Chitale, Mohammed Morsey, Louise Swift* and Krishna Sethia Department of Urology, Norfolk & Norwich...
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Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

The purpose of this meta-analysis was to assess the effects of extracorporeal shock wave therapy...
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Extracorporeal shock wave therapy for nonunion of the tibia

Delayed and nonunion of the tibia are not uncommon in orthopedic practice. Multiple methods of...
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Novel Approach to Obtain an Activated Fat Graph

One of the mainstays of facial rejuvenation strategies is volume restoration, which can be achieved...
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ESWT for retracting scars of the hand

Department of Medical Sciences, Oral and Biotechnology, ‘‘G. D’Annunzio’’ University, Chieti, Italy;  Department of Dermatology,...
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Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

Placebo controlled double-blinded, prospectively randomized clinical trial with 17 patients (11 verum, 5 placebo) for evaluation of cellulitetreatment with Acoustic Wave Therapy, (AWT(®))...
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Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

Mesenchymal stem cells are regarded as common cellular precursors of the musculoskeletal tissue and are...
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Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

A. SKOLARIKOS, M.D., ALARGOF, M.D., RIGAS, M.D., DELIVELIOTIS, M.D. and E. KONSTANTINIDIS, M.D – To assess in...
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Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Urology Section, Department of Surgery, University of Catania, Catania, Department of Urology, University of Florence, Andrology...
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Extracorporeal shock waves, a new non-surgical method to treat severe burns

Department of Plastic, Aesthetic and Reconstructive Surgery and Burn Center Vall d’Hebron University Hospital, Autonomous...
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Motor and Sensory Schwann Cell Phenotype Commitment is Diminished by Extracorporeal Shockwave Treatment in vitro

The gold standard for peripheral nerve regeneration uses a sensory autograft to bridge a motor/sensory...
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Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study

Currently, there are no effective therapy strategies for idiopathic, non-organic vulvodynia in women. ESWT (extracorporeal...
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Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

The current ‘‘gold standard’’ for treatment of chronic fracture nonunion in the metaphyseal-diaphyseal region of...
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​Prospective randomized phase II trial of accelerated reepithelialization

Christian Ottomann, MD, Alexander Stojadinovic, MD, FACS,  Philip T. Lavin, PhD,§ Francis H. Gannon, MD,...
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Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System

Angiotensin-converting enzyme (ACE2) has a multiplicity of physiological roles that revolve around its trivalent function:...
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Evaluation of extracorporeal shock wave therapy for osteoarthritis

Lameness, and more specifically, joint disease, causes significant loss of use of athletic horses and...
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Ultrasound Based Brain Stimulation

Ultrasound based brain stimulation techniques bay become a powerful new technique to modulate the human...
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Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and aging

Director Kompass Health Associates, Centre for Regenerative Health, Sports Performance & Research – Auckland, New...
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Extracorporeal shockwave therapy shows site-specific effects in osteoarthritis of the knee in rats

Methods: Sixty SD rats were divided into five groups. Group I was the control and...
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Mechano-transduction effect of shock waves in the treatment of lumbar facet joint pain:Comparative effectiveness evaluation

(Charles University in Prague, 2nd Faculty of Medicine, Department of Neurology, Prague, Czech Republic Center...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Biologic Response

LL37 and shock waves

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing by ATP release coupled extracellular signal-regulated kinase (ERK) activation

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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