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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Plantar Fasciitis Medical Devices That Relieve Pain

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Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

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Purple Heart Recipient Uses Innovative Technology to Treat Fellow Veterans

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​STORZ MEDICAL’s NEUROLITH® receives CE approval – Transcranial Pulse Stimulation (TPS) on the central nervous system of patients with Alzheimer’s disease

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Shock Wave Therapy (MI-ESWT) for Plantar Fasciitis

​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Shock waves promote spinal cord repair via TLR3

“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

Shock Waves Reach Dental Implantology (Spanish)

Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

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Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

Exploring Regenerative Treatment for Knees After Failed Conservative Care

Regenerative Treatment for Knees That Fail Conservative Care

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Doubts over heart stem-cell therapy

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Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

SoftWave: Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

The Applied Mechanical Vibration as Extracorporeal Shock Wave

Biological mechanism of shockwave in bone

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The Clinician’s Guide to Shockwave Therapy- Evidence, Safety, and Technology

The Clinician’s Guide to Shockwave Therapy: Evidence, Safety, and Technology

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

A prospective, randomized, controlled, single centre trial to assess the efficacy and safety of radial extracorporeal shockwave therapy in patients with chronic non-specific low back pain

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Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag​)

Lohse – Busch ISMST Presentation

Spark Wave® Therapy Improves Cardiac Function

Pickleball Star Riley Newman Speeds Recovery With SoftWave Therapy

Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

​Extracorporeal shock wave therapy in periodontics: A new paradigm

Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

Spark Wave® Therapy Ameliorates Urinary Incontinence

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Dr Irwin Goldstein Dinner Presentation – Nashville

Set up Instructions

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Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

7 Red Flags That Signal a Risky Shockwave Device

7 Red Flags That Signal a Risky Shockwave Device

Knee Pain Relief through Advanced Shockwave Therapy

SoftWave: Leading the Way in Knee Pain Relief through Advanced Shockwave Therapy

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy

Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

​Prospective randomized phase II trial of accelerated reepithelialization

Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

​Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

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The Best Alternatives to Rotator Cuff Surgery

Alternatives to Rotator Cuff Surgery

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

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Acoustic Field of a Ballistic Shock Wave Therapy Device

Assessment of IL-1Beta and VEGF Concentration in Rat Model During Orthodontic Tooth Movement and Extracorporeal Shock Wave Therapy

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Effect of penile rehabilitation with low intensity extracorporeal shock wave therapy

Shockwave Therapy for Muscle Pain and Injuries

Shockwave Therapy for Muscle Pain and Injuries

TRT SoftWaves® – a new regenerative therapy for paraplegia

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Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Low–Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

Cellular mechanotransduction: putting all the pieces together again

​Extracorporeal shock wave therapy: What? Why? Safety?

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

SoftWave Therapy Averts Amputation for Former College Football Coach

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Storz Modulith Shockwave Systems- Mechanisms, Clinical Context, & Alternatives

Storz Modulith Shockwave Machines: Efficacy & Alternatives Explored

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Low-Intensity Shockwave Therapy May Be Beneficial for Women With Provoked Vestibulodynia

The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

SoftWave TRT vs Storz Shockwave Machines Compared

A randomized, controlled clinical study to investigate the safety and efficacy of acoustic wave therapy in body contouring

Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury

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ESWT Therapy for Treatment of Keloid Scars

Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Neuropathy

Shockwave Therapy for Neuropathy

Alternatives to Surgery

Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

Lithotripter outcomes in a community practice setting: Comparison of an electromagnetic and an electrohydraulic lithotripter

Minimally invasive treatment of Peyronie’s disease: evidence-based progress

Impact of Extracorporeal Shock Wave Therapy (ESWT) on Orthodontic Tooth Movement – A Randomized Clinical Trial

Principles of Shock Wave Therapy

Shock wave therapy alone has no impact on cancer growth

Shockwave therapy in stress fractures

Doctor Uses Shockwave Therapy to Heal Nearly Severed Foot

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Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

Adhesive Capsulitis Management with Advanced Shockwave Therapy

SoftWave: Empowering Adhesive Capsulitis Management with Advanced Shockwave Therapy

Efficacy and safety of extracorporeal shock wave therapy for orthopedic conditions: a systematic review on studies listed in the PEDro database

Regenerative Therapies for Hip Pain and Tendinopathy

Regenerative Therapies for Hip Pain and Tendinopathy

Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

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New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

SoftWave Therapy® Represents a Valuable Addition in the Treatment of Hard-to-Heal Wounds

Acoustic wave therapy for cellulite, body shaping and fat reduction.

Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines Compared

Current concepts of shockwave therapy in stress fractures

Extracorporeal shockwave therapy shows site-specific effects in osteoarthritis of the knee in rats

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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Shockwave Therapy: Does it Hurt?

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Biological Principles – Mechanotransduction

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Scientific Reports – Gene transfection by shock waves

Extracorporeal shockwave therapy induces alveolar bone regeneration

Treatment of scaphoid waist nonunion

What Is HydroWave Therapy? Mechanism, Applications, and Clinical Context

What Is HydroWave Therapy? How It Works, Clinical Uses, and Evidence

Angiogenic response to extracorporeal shock wave treatment in murine skin isografts

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

The Physics of Shock Wave Lithotripsy

​Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease

Angiogenic response upon shock wave treatment of the ischaemic muscle

Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Motor and Sensory Schwann Cell Phenotype

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SoftWave OrthoGold

Best Medical Devices for Treating Wrist Tendonitis 

Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

How Does Shockwave Therapy Work?

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

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Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite e A current metaanalysis​ -(Plastic, Hand and Burn Surgery, University of Schlewig Holstein, Lubeck, Germany​)

SoftWave : Transforming Foot Pain Management with Advanced Shockwave Therapy

SoftWave vs Shockwave Technology Explained 

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UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Plantar Fasciitis Medical Devices That Relieve Pain

Plantar Fasciitis Medical Devices That Relieve Pain

Equine extracorporeal shock wave therapy

SoftWave Celebrates Pro Success of Golfer Jake Peacock and Baseball Player Reid Worley, Highlighting Injury Prevention Breakthroughs

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Using Sound to Battle Opioid Crisis

Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy

Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Novel Approach to Obtain an Activated Fat Graph

Best Noninvasive Options for Regenerative Back Treatment Without Injections

Best Options for Regenerative Back Treatment Without Injections

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Effects of the extracorporeal shock wave therapy on the skin: an experimental study

Alternatives to Orthopedic Surgery in Outpatient Rehab

Alternatives to Orthopedic Surgery in Outpatient Rehab

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Extracorporeal shockwave therapy for atrophic and oligotrophic nonunion of tibia and femur in high energy trauma patients. Case series.

Non‑surgical Regenerative Treatments Integrating with PT

Non‑surgical Regenerative Treatments Integrating with PT

Extracorporeal shockwave: mechanisms of action and physiological aspects…

Extracorporeal shockwave therapy (ESWT) ‒ First choice treatment of fracture non-unions

ISSWSH Abstract

Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

​Antibacterial effects of extracorporeal shock waves

AUVA letter‒ Successful treatment of delayed and non-union fractures

LL37 and shock waves

​The biologic effects of SoftWaves and rationale for spine and brain therapy

In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Extracorporeal shock waves Improve pareses in 8 cases of spinal cord injury and 3 cases of myelomeningocele.

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Three-time Super Bowl Champ RandyCross Finds Pain Relief With InnovativeTherapy from SoftWave TRT

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Mesenchymal stem cells: Myths and reality

Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

Reduce Inflammation Naturally With Shockwave Therapy

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Shock wave therapy enhances neuronal sprouting and improves neuronal survival

Alternatives to Back Surgery Doctors Should Consider

Alternatives to Back Surgery Doctors Should Consider

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Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Zimmer enPulsPro Shockwave Machines-

Zimmer enPulsPro Shockwave Machines: Efficacy & Alternatives

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

Exploring Alternatives to Pain Treatment: Your Path to Natural Relief

Focused vs Radial Shockwave Therapy Machines Explained 

Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

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Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

SoftWave Therapy for Knees

SoftWave Therapy vs. Stem Wave & Acoustic Wave Devices for Knee Pain

EPAT Shockwave Therapy Efficacy & Alternatives Explained

EPAT Shockwave Therapy Efficacy & Alternatives Explained

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Shock wave treatment of muscle stem cells – a new implementation for regeneration

MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

MSC-exosome: A novel cell-free therapy for cutaneous regeneration

Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and ageing

Extracorporeal shock wave therapy (ESWT) in urology:a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain

Benefits of Spark Wave Therapy in neuronal regeneration

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The influence of comorbidities – ESWT for chronic soft tissue wounds

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Macrophage migration induces angiogenesis

Shock waves induce angiogenesis via exosome release

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​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

Shockwave Therapy for the Treatment of Cancer

Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Extracorporeal Shockwave Therapy for Arthritis Treatment

Extracorporeal shock wave therapy: clinical applications and regulation

Extracorporeal Magnetic Transduction Therapy Explained

Extracorporeal Magnetic Transduction Therapy Explained

What Is Pulse Wave Therapy & Does It Work for Patients?

What Is Pulse Wave Therapy & Does It Work for Patients?

Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

SoftWave on Elbow

Radial Shockwave Therapy Benefits & Alternatives

The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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