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SoftWave Research
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SoftWave TRT Lands Prestigious VA Contract Revolutionizing Pain and Wound Management for Veterans
Amazon Healthcare veteran Chris Holt brings experience and a bold vision to lead SoftWave TRT's...
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Sticky Post
Seven Trends in Healing for 2023
Smith, William The pace of innovation in regenerative medicine keeps getting faster. At clinics across...
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Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement—a randomized clinical trial
This randomized clinical trial investigated the effect of extracorporeal shock waves on the amount of...
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Technology Assessment “Wound Care” dermagold100
MTS-Science – Acute wounds are caused exogenously by traumatic (e.g. mechanical, chemical, thermical) or iatrogenic (e.g. surgical)...
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Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)
RESULT Among 187 patients with confirmed COVID-19, 144 patients (77%) were discharged and 43 patients...
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Extracorporeal shockwave therapy for atrophic and oligotrophic nonunion of tibia and femur in high energy trauma patients. Case series.
High energy diaphyseal fractures constitute a complicated matter for trauma units and urgent medical and...
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Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: A single-center, randomized, placebo-controlled clinical trial
In this randomized, placebo-controlled clinical trial, we investigated the effect of noninvasive extracorporeal shock waves...
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The Role of the Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Radical Prostatectomy: A Randomized Clinical Trial
Click here to read more.
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Angiogenic response upon shock wave treatment of the ischaemic muscle
Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.
Tissue Regeneration Technologies – A four patient pilot trial was conducted in 2018 including four...
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Motor and Sensory Schwann Cell Phenotype Commitment is Diminished by Extracorporeal Shockwave Treatment in vitro
The gold standard for peripheral nerve regeneration uses a sensory autograft to bridge a motor/sensory...
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Extracorporeal shock wave therapy surpresses the early proinflammatory immune response to a severe cutaneous burn injury
Davis T, Stojadinovic A, Anam K, et al.Int Wound J. 2009; 6:11-21 Click here to read...
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Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial
This RCT investigated the effect of non-invasive extracorporeal shockwaves on tooth mobility in orthodontic patients...
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Sports medicine practitioners embrace benefits of extracorporeal shock wave therapy
Mayo Clinic – Extracorporeal shock wave therapy (ESWT) is a noninvasive treatment that involves delivery of shock...
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Best Shockwave Therapy Machine For Providers
Extracorporeal shockwave therapy (ESWT) is a viable, growing treatment option for patients who are seeking...
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Zapping chronic tendon pain
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Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment: A Systematic Review of the Literature
Robert Dymarek, PhD, PT; Tomasz Halski, PhD, PT; Kuba Ptaszkowski, PhD, PT; Lucyna Slupska, PhD,...
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The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.
Wolff et al.Ultrasound Med Biol. 2011 Jul;37(7):1111-9. Click here to read more.
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The Roll of Spark Waves in the Management of Chronic Wounds.
Antibiotic-resistant bacterial colonies often produce biofilms (a defensive mechanism that creates a physical protective barrier...
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Angiogenic response to extracorporeal shock wave treatment in murine skin isografts
Stojadinovic A, Elster E, Anam EA, et al.Angiogenesis. 2008; 11(4):369-380 Click here to read more.
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Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy
Tibial non-unions are common cause of demanding revision surgeries and are associated with a significant...
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Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag)
A prospective, randomized, double‐blinded, controlled pilot trial of 24 abdominoplasty patients revealed that preoperative application...
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Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study
A. SKOLARIKOS, M.D., ALARGOF, M.D., RIGAS, M.D., DELIVELIOTIS, M.D. and E. KONSTANTINIDIS, M.D – To assess in...
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Ultrasound Brain Stimulation Piloted in Alzheimer Study
Patients with probable Alzheimer disease (AD) had sustained memory improvements months after ultrasound brain stimulation...
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Successful treatment of nonunions with orthogold280
A pseudarthrosis is defined as a non healing fracture from which a false joint develops....
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Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury
(Swiss Paraplegic Centre Nottwil) – Spasticity is the most problematic self-reported secondary medical problem in patients...
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Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells
Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate...
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ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration
Hercher et al.TERMIS World Congress 2018 in Kyoto, Japan Click here to read more.
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Benefits of Unfocused Li-ESWT for Erectile Dysfunction and Nocturia
When health issues arise, it is crucial to know what treatment options are available and...
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Effects of the extracorporeal shock wave therapy on the skin: an experimental study
Thayná Melo de Lima Morais, Patrícia Froes Meyer, Liliane Santos de Vasconcellos, Julio Costa e Silva, Ito Ferreira e...
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Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis
Knowing the most effective treatment options for your patients is crucial for their speedy recovery....
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FUNDAMENTALS OF VIBRATION-INDUCED, CELL POLARIZING TREATMENT MALIGNER DISEASES
Professor Dr.-Ing. habil. Axel E. Theuer Click here to read more.
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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix
Mechanical stimulation of acute ischemic myocardium by shock wave therapy (SWT) is known to improve...
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Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting
Click here to read more.
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OrthoGold 100TM
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Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes
Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor...
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Using acoustic therapy to prevent opioid addiction.
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The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.
Rani S, Ritter T – Wound healing is a complex process and often delayed in patients with...
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Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model
To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress...
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Unfocused extracorporeal shock waves induce anabolic effects in rat bone
van der Jagt OP, Piscaer TM, Schaden W, et al.J Bone Joint Surg Am. 2011; 93(2):38-48...
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In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes
Ottomann C., Antonic V., Münch S., et al.J Bioengineer & Biomedical Sci 2015, 6:12015 Click here...
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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)
Click here to read more.
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Extracorporeal shockwave treatment for chronic diabetic foot ulcers
Seventy-two patients with 72 chronic diabetic foot ulcers were randomly divided into two groups of...
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Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)
(Wei Wei, Hua-yu Tang, Yu-zhi Li, Tian-shu Wang) – : Previous clinical trials have reported that...
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Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and aging
Director Kompass Health Associates, Centre for Regenerative Health, Sports Performance & Research – Auckland, New...
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Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report
Rajendra Kashinath Shimpi, Ravi Jineshkumar Jain Department of Urology and Genito-Urinary Surgery, Ruby Hall Clinic,...
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Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture
As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for...
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Shock wave therapy alone has no impact on cancer growth
Cancer remains one of the leading causes of morbidity and mortality throughout the world. Several...
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Scientific Reports – Gene transfection by shock waves
Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids...
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Principles of Shock Wave Therapy
John A. Ogden, MD; Anna Tóth-Kischkat, PhD; and Reiner Schultheiss, PhD Click here to read...
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Spark Wave® Therapy Ameliorates Urinary Incontinence
MTS-Science April 14th, 2019. Stress urinary incontinence (SUI) is the involuntary leakage of urine during activities such...
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MTS Spark WaveTM Technology and its mechanism of action in wound management
MTS-Science – Diabetic foot ulcers are one of the most serious complications of diabetes mellitus and...
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Alternatives to Cortisone Shots
If you have a patient with debilitating joint pain, you may have recommended or administered...
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Sound Frequency Healing: The Spark of Life
By: Dr. Matt DiDuro How Sound Frequency Healing Works SoftWave’s sound frequency healing technology, known...
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Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.
The objective of this study is to demonstrate the efficacy and safety of AWT(®), combining two different mechanical...
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Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy
Graber et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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The Physics of Shock Wave Lithotripsy
Shock wave lithotripsy (SWL) was introduced in the 1980s for the treatment of urinary stones...
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Extracorporeal shock wave therapy for nonunion of the tibia
Delayed and nonunion of the tibia are not uncommon in orthopedic practice. Multiple methods of...
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Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors
Shockwave fractures treatment promotes bone healing of nonunion fractures. In this study, we investigated whether...
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How Shockwave Therapy Breaks Down Scar Tissue
The benefits of Extracorporeal Shock Wave Therapy (ESWT) when used to treat chronic and acute...
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Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits
We tested whether shock wave (SW) offers additional benefits in improving left ventricular (LV) function...
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Penile low intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic Erectile Dysfunction since 2 to 10 years: A prospective, randomized, placebo-controlled study
MTS Science – Several animal and human studies have evaluated the role of low-intensity extracorporeal shockwave...
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Minimally invasive treatment of Peyronie’s disease: evidence-based progress
Department of Urology, Eastern Virginia Medical School, Norfolk, VA, *Division of Urologic Surgery, University of...
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Influence of medical shock waves on healthy muscle tissue
Competitive sport requires each athlete to be at peak performance at all times. This is...
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Alternative Treatment for Erectile Dysfunction with the Urogold 100™
MTS Science Published on Jun 21, 2016 – The improvement of Erectile Dysfunction through the treatment with...
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Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease
The use of non-invasive brain therapies has become a hot topic recently. Alzheimer’s and Parkinson’s...
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The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial
(Shih-Feng Lin, Yi-Jen Chen, Hung-Pin Tu , Chia-Ling Lee, Ching-Lin Hsieh , Wen-Lan Wu ,...
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ISSWSH Abstract
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The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders
Shockwave therapy was originally developed to disintegrate urinary stones 4 decades ago1 . Since then,...
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Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells
Human bone marrow stromal cells (hBMSCs) bear tremendous clinical potential due to their immunomodulatory properties...
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Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis
Louise Helen Hitchman, Joshua P. Totty, Ali Raza, Paris Cai, George E. Smith, Daniel Carradice,...
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The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification
(Tz-Yan Lin, Jing-Ting Chen, Yu-Yu Chen, Tien-Wen Chen , Chia-Ling Lee, Chia-Hsin Chen, Mao-Hsiung Huang)...
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SoftWave Tissue Regeneration Technologies Receives Innovative Technology Contract from Vizient For DermaGold®
SoftWave Tissue Regeneration Technologies announced its DermaGold,® an advanced wound care technology, has received an...
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Influence of extracorporeal shock wave therapy (ESWT) on bone turnover markers in organisms with normal and low bone mineral density during fracture healing: a randomized clinical trial
Low bone mineral density (BMD) leads to metaphyseal fractures, which are considered of delayed, qualitatively...
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Shock wave application to cell cultures
Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and ageing
Kenneth Craig Vincent, Wolfgang Schaden, Laupepa Aposetolo Karalus, Jacqueline Craig Huges, Daniel Poratt – The ‘Niche’ is...
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A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease
Alessandro Palmieri, Ciro Imbimbo, Nicola Longo, Ferdinando Fusco, Paolo Verze, Francesco Mangiapia, Massimiliano Creta ,...
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Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy
Ottomann C, Hartmann B, Tyler j, et al.J Am Coll Surg. 2010; 211(3):361-7 Click here to...
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Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study
Currently, there are no effective therapy strategies for idiopathic, non-organic vulvodynia in women. ESWT (extracorporeal...
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Shock Waves Reach Dental Implantology (Spanish)
Lithotripsy or Shock Wave Therapy is proving to be an effective non-invasive treatment to regenerate...
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Extracorporeal shock wave therapy relieved pain in patients with coccydynia: a report of two cases
(Yousef Marwan, MBBS, Wael Husain, MBBS, FRCSC , Waleed Alhajii, MBBS, MSc, Facharztb , Magdy...
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Reduce Inflammation Naturally With Shockwave Therapy
Like all things, inflammation is good and healthy in moderation, but when it becomes chronic,...
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MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy
Click here to read more.
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Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy
Christian Ottomann, MD, Bernd Hartmann, MD, Josh Tyler, MD, Heike Maier, MD, Richard Thiele, MD,Wolfgang...
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Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function
Liver cirrhosis is a life-threatening problem; a considerable proportion of patients with liver cirrhosis progress...
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Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis
Van der Jagt et al.Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society,...
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Pilot Trial, First Report Worldwide for Unfocused SoftWave® Therapy (uESWT) for the Treatment of Testicles to Improve Testicular Size and Function
(Georgia Urology, Atlanta, USA. 2018) Testosterone in males is produced in the testicles. With aging...
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Chris Holt Takes the Helm as New CEO of SoftWave Tissue Regeneration Technologies, Ushering in a New Era of Growth
Amazon Healthcare veteran Chris Holt brings experience and a bold vision to lead SoftWave TRT's...
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Shockwave Therapy for Calcific Tendonitis
Shoulder pain is a prevalent complaint that affects millions of individuals worldwide. In fact, it’s...
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Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures
Introduction: As of now, the role of extracorporeal shockwave therapy (ESWT) in the treatment of...
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Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy
Ultrasound based brain stimulation techniques may become a powerful new technique to modulate the human...
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A prospective, randomized, controlled, single centre trial to assess the efficacy and safety of radial extracorporeal shockwave therapy in patients with chronic non-specific low back pain
(Balagué et al., 2012). Non-specific low back pain is common and affects people of all...
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Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
Jieyuan Zhang, Junjie Guan, Xin Niu, Guowen Hu, Shangchun Guo , Qing Li , Zongping...
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The Biologic Effects of SoftWaves™and Rationale for Spine and Brain Therapy
Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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The Effect of Different Doses of Extracorporeal Shock Waves on Experimental Model Mandibular Distraction
Distraction osteogenesis (DO) is widely used treatment for the bone deformities. In addition extracorporeal shock...
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Benefits of Spark Wave Therapy in neuronal regeneration
(MTS Science) – Extracorporeal shock wave therapy (ESWT) is widely used in clinical practice. In addition to...
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Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?
In this study we examined the effects of two different repeated Extracorporeal Shock Waves (ESW)...
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ESWT Therapy for Treatment of Keloid Scars
Click here to read more.
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Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses. – PubMed – NCBI
8 horses were treated with ESWT at 6 locations along the neck at 36, 24,...
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CM Shockwave Before And After Use
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Ultrasound Based Brain Stimulation
Ultrasound based brain stimulation techniques bay become a powerful new technique to modulate the human...
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Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian men
Eric Chung, University of Queensland, Department of Urology, Princess Alexandra Hospital, Brisbane, AndroUrology Centre, St...
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Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats
Van der Jagt et al.Journal of Orthopaedic Research, 31(5), 768–775. https://doi.org/10.1002/jor.22258. Click here to read more.
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TRT SoftWaves® – a new regenerative therapy for paraplegia
Extracorporeal softwave therapy (ESWT) is widely used in clinical practice. In addition to its original...
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International Society for Medical Shockwave Treatment- ESWT BASIC PHYSICAL PRINCIPLES
2016 Dietz-Laursonn Click here to read more.
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Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway
Erectile dysfunction is highly prevalent in type II diabetes mellitus.Low intensity extracorporeal shock wave therapy...
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Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers
We report the case of a 78-year-old woman with a history of hypertension, deep vein...
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Set up Instructions
Video for setting up the device, inserting the applicator and water cartridge, and how to...
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“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells
The stromal vascular fraction (SVF) is a heterogeneous cell population derived from the adipose tissue....
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Molecular changes in diabetics foot ulcers
The Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College...
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Using Sound to Battle Opioid Crisis
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Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling
Holfeld et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.
Breast cancer is characterized by rapid aberrant growth of tissue in the mammary glands. The...
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Latest Basic Research Abstracts
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The influence of comorbidities – ESWT for chronic soft tissue wounds
Department of Surgery, Austrian Armed Forces Hospital-Vienna, Vienna, Austria; AUVA Trauma Center Meidling, Vienna, Austria; ...
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The Best Alternatives to Rotator Cuff Surgery
Rotator cuff injuries are all-too-frequent in the United States, affecting millions of people throughout the...
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A neural model for chronic pain and pain relief by extracorporeal shock wave treatment
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Optimization of screw fixation in rat bone with extracorporeal shock waves
Koolen et al.Journal of Orthopaedic Research. https://doi.org/10.1002/jor.23615. Click here to read more.
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Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China
Since December, 2019, an outbreak of pneumonia caused by a novel coronavirus (SARS-CoV-2) has raised...
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Erectile Dysfunction before and after results under ultrasound
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The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction
A Systematic Scoping Review of Pre-Clinical Studies – Using Cochrane’s methodologic recommendations on scoping studies and...
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Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?
Schaden W, Mittermayr R.Jatros Orthopädie & Rheumatologie. 5/2011; 72-74 Click here to read more.
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Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1
Extracorporeal shock-wave (ESW) treatment has been shown to be effective in promoting the healing of...
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MTS Science White Paper – Softwave – Pain Therapy
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Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shock wave therapy device
Extracorporeal shock wave therapy (ESWT) uses acoustic pulses to treat certain musculoskeletal disorders. In this...
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Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria
Click here to read more.
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Acoustic wave therapy for cellulite, body shaping and fat reduction.
Hexsel D, Camozzato FO, Silva AF, Siega Cellulite is a commonality among most women and some men. As...
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Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial
Fleckenstein et al.Arch. Phys. Med. Rehabil. 98, 923–930 (2017). Click here to read more.
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Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System
Angiotensin-converting enzyme (ACE2) has a multiplicity of physiological roles that revolve around its trivalent function:...
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4 U. S. Patents issued on July 19, 2022
SoftWave officially has been granted 4 new patents as of July 19, 200. They include...
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Equine extracorporeal shock wave therapy
Extracorporeal shock wave therapy (ESWT) is an accepted form of treatment for chronic cases of...
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Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)
Ligament-to-bone and tendon-to-bone interfaces (entheses, osteotendinous junctions [OTJs]) serve to dissipate stress between soft tissue...
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Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review
Extracorporeal shock wave therapy (ESWT), first described in the eighties for the treatment of urolithiasis,...
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TISSUE REGENERATION TECHNOLOGIES, LLC Establishment Registration & Device Listing
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Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy
Dental implants are a routine procedure within the therapeutic range of dentists. Many loading protocols...
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Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization
Nägele et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice
Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading...
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Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis
The goal for treating osteoarthritis (OA) is finding ways to decrease joint pain and dysfunction...
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Case Study 1 shows an 80-year old female patient who developed a large infected decubitus ulcer from a lengthy stay in a hospital bed following a knee operation.
She was treated with high dose antibiotics. Surgeons recommended a colostomy and several operations to...
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Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury
Thomas A Davis, Alexander Stojadinovic, Khairul Anam, Mihret Amare, Shruti Naik, George E Peoples, Douglas...
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Low-energy Extracorporeal Shock Wave Therapy (ESWT) on secondary fibrolymphedema
Breast cancer diagnosis and treatment with sentinel lymph node biopsy, axillary lymph node dissection and...
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DIGEST Guidelines for Extracorporeal Shock Wave Therapy
Click here to read more.
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Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis
Carlotta Scarpa, MD, PhD, Vincenzo Vindigni, MD, PhD, and Franco Bassetto, MD Acoustic waves are mechanical waves...
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ISMST (International Society for Medical Shockwave Treatment)
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Stemwave Therapy
What is Stemwave Therapy? Stemwave therapy is a commonly used term that can be synonymous...
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Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro
Mesenchymal stem cells are regarded as common cellular precursors of the musculoskeletal tissue and are...
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Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets
Treatment can be used alone or in combination with other therapies. Both young, athletic dogs...
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Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy
Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Cairo, Egypt Department of General...
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Effect of penile rehabilitation with low intensity extracorporeal shock wave therapy on erectile function recovery following robot- assisted laparoscopic prostatectomy
Shogo Inoue, Tetsutaro Hayashi, Jun Teishima, Akio Matsubara Click here to read more.
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Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves
It was found a statistically significant difference between the study groups and control group in...
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The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent
Fuchs et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model
Introduction—Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from...
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Softwave® Tissue Regeneration Technologies Announces Landmark Trial for Acute Traumatic Spinal Cord Injuries
SoftWave® Tissue Regeneration Technologies, a disruptive bio-medical device company, announces the beginning of a trial...
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MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)
Cellulite is a multifactorial condition that is present in 80-90 % of post-pubertal women, commonly found...
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Shock wave therapy for osteoinduction
Koolen et al. 20th ISMST Congress in San Sebastian, Spain Abstract P33 Click here to...
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The effect of shock waves on in vitro cartilage development in silk scaffolds
Szwarc et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Extracorporeal Shock Wave Device for Treatment of Chronic Wounds
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New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)
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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation
Shockwave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the...
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Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy
Extracorporeal shockwave therapy (ESWT) is used in a number of indications in the medical field....
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Effectiveness of Extracorporeal Shock Wave Lithotripsy to treat Dystrophic Calcinosis Cutis
Delgado-Marquez et al.Actas Dermosifiliogr. 2015 Mar;106(2):140-3. doi: 10.1016/j.ad.2014.06.006. Click here to read more.
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Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?
Onger et al.Med Oral Patol Oral Cir Bucal. 2017 Mar 1;22(2):e251-e257.2017 Click here to read...
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Comprehensive Urology to Utilize New Shockwave Therapy Device: PulseWave
PRESS RELEASE PR Newswire 2018 – Comprehensive Urology Medical Group, one of the nation’s leading...
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Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy
Scaphoid nonunion remains challenging for hand surgeons. Several treatment options are available such as: non-vascularized or...
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End-stage Heart Failure with COVID-19: Strong Evidence of Myocardial Injury by 2019-nCoV
A novel coronavirus (2019-nCoV) was identified as the cause associated with emerging pneumonia (COVID-19) detected...
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Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence
Tepeöylü et al.Journal of Tissue Engineering and Regenerative Medicine, 12(1), e486–e494. https://doi.org/10.1002/term.2317.2018 Click here to read...
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Biological mechanism of shockwave in bone
Shockwave is a rapid, short duration acoustic wave that carries energy and can propagate through...
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Evaluation of extracorporeal shock wave therapy for osteoarthritis
Lameness, and more specifically, joint disease, causes significant loss of use of athletic horses and...
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Case Series of Low Intensity Shock Wave Therapy for Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Shoskes et al., Cleveland Clinic, United StatesAUA Congress in Lisbon, Portugal Click here to read...
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Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy
Priglinger et al.Cytotherapy. 2017 Sep;19(9):1079-1095. doi: 10.1016/j.jcyt.2017.05.010. Epub 2017 July 19, 2017 Click here to read...
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Urological Times Cover – Scroll to Page 18 – 19
Urological Times – It’s hard to argue against an erectile dysfunction treatment that is potentially...
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Extracorporeal shock wave therapy effectively prevented diabetic neuropathy
We tested the hypothesis that extracorporeal shock wave (ECSW) therapy can effectivelyprotect sciatic nerve (SN)...
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SoftWave TRT Selected to Exhibit DermaGold at Vizient Innovative Technology Exchange
Amazon Healthcare veteran Chris Holt brings experience and a bold vision to lead SoftWave TRT's...
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Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats
We hypothesized that combined treatment with extracorporeal shock wave and bone marrow-derived endothelial progenitor cells...
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Lithotripter outcomes in a community practice setting: Comparison of an electromagnetic and an electrohydraulic lithotripter
Bhojani et al.J. Urol. (2015). doi:10.1016/j.juro.2014.09.117. Click here to read more.
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Effects of Shock Waves on Expression of IL-6, IL-8, MCP-1, and TNF- alpha Expression by Human Periodontal Ligament Fibroblasts: An In Vitro Study
Extracorporeal shock wave therapy (ESWT) can modulate cell behavior through mechanical information transduction. Human periodontal...
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Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart
Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It...
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ESWT for resident stress fractures in athletes.
Stress fractures are major concerns with athletes. It is sometimes difficult to repair, resulting in...
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Doubts over heart stem-cell therapy
The cells are then injected back into the patient, to help repair damaged tissue. Original...
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Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite
Research Institute of Environmental Medicine at Heinrich-Heine University, D-40021 Duesseldorf,Germany In vivo measurements in 26...
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Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases
(Yousef Marwan, • Bashar Dahrab • Ali Esmaeel • Samir Abdulrazik Ibrahim • Jassim Al-Failakawi)...
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Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial
Holfeld et al. 20th ISMST Congress in San Sebastian, Spain Abstract P30 Click here to...
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Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model
Extracorporeal shock wave therapy has been used in various clinical conditions as a result of...
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Shockwave Therapy for Achilles Tendonitis
Achilles tendonitis is a common condition that causes pain and swelling in the Achilles tendon,...
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MSC-exosome: A novel cell-free therapy for cutaneous regeneration
Peipei Wu, Bin Zhang, HuiShi, Hui Qian, Wenrong Xu – Cutaneous regeneration is a dynamic and complex process...
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First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)
IRB study at Georgia Urology, Atlanta, USA – Since 2007 at least 250.000 ED patients have...
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Effect of shock waves on macrophages
Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Effects of ESWT on glycosaminoglycan expression during bone healing
Several cases of delayed bone consolidation have been treated with extracorporeal shock wave therapy (ESWT) to improve bone...
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Exosomes and Cardiovascular Protection
Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called...
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Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury
Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular...
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Penile low intensity shock wave therapy for PDE5i non responders: A prospective, randomized, placebo-controlled study
Fundació Puigvert, Barcelona, Spain European Congress of Andrology, Rotterdam, Netherlands Click here to read more.
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Novel Approach to Obtain an Activated Fat Graph
One of the mainstays of facial rejuvenation strategies is volume restoration, which can be achieved...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes
Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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ESWT for Acute and Chronic Soft Tissue Wounds
Wolfgang Schaden, M.D., Richard Thiele, M.D., Christine Kölpl, M.D., Michael Pusch, M.D., Aviram Nissan, M.D.,...
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Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus
Mononuclear invasion of Langerhans islet and the ensuing insulitis triggers signal-transduction for the autoimmune mediated...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction
Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears
Characteristics of chronic rotator cuff tears include continuous loss of tendon structure as well as...
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Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome
A phase III, randomized, double blind controlled with placebo study – (MTS-Science) – Chronic Prostatitis/ Chronic...
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SoftWave TRT Leads the Charge: Secures CPT Code Approval for Groundbreaking men’s sexual health and Shockwave Therapy
Amazon Healthcare veteran Chris Holt brings experience and a bold vision to lead SoftWave TRT's...
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Dr. Lohse Bush, first brain treatments
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Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury
It has been hypothesized that there are two mechanisms of acute traumatic spinal cord injury...
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Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction
MTS Science – Low Intensity Shock Wave (LiSW) has emerged as a therapy for vasculogenic erectile...
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Biologic Response
The link between shockwaves and innate immunity – the main working mechanism?
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LL37 and shock waves
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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)
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Biological Principles – Mechanotransduction
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Biological mechanism of musculoskeletal shockwaves
Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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The biologic effects of SoftWaves and rationale for spine and brain therapy
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IVSWT Water Bath V2.0 Manual
The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia
Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures
Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing by ATP release coupled extracellular signal-regulated kinase (ERK) activation
Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
Read More
Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction
Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts
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Lohse – Busch ISMST Presentation
High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages
Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes
Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection
Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle
Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3
(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation
(University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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Become a Provider
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Research
FDA Research
SoftWave Literature
Biologic Response
Bone Healing
Brain, Spine and Nerve
Cardiology Research
Cancer Research
Cosmetics / Aesthetics Research
Dental Research
Integrative Medicine
Modulation of Inflammation
Opioid Addiction Research
Organ Regeneration
Physics
Sports Medicine Orthopedics
Respiratory/Coronavirus
Stem Cells Research
Urology
Sexual Health Research
Veterinary
Wound Care Research