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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Peripheral Nerve Regeneration

Peripheral Nerve Regeneration

​Extracorporeal shock wave therapy: What? Why? Safety?

Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

Extracorporeal shockwave therapy induces alveolar bone regeneration

Shockwave Therapy for Plantar Fasciitis

Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

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What are the Side Effects of SoftWave Therapy

Spark Wave® Therapy Ameliorates Urinary Incontinence

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Orthospec Shockwave System Clinical Uses, Evidence, and Limitations

Orthospec ESWT System Explained

Non‑surgical Regenerative Treatments Integrating with PT

Non‑surgical Regenerative Treatments Integrating with PT

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Managing Pain with Shockwave Therapy for Muscles

Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

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Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Prof. M. Kravchik. Focused shockwave therapy in the treatment of the spine. Oxford, UK Non-invasive treatment of herniated discs by focused shock wave therapy

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Effective Medical Devices for Treating Tarsal Tunnel Syndrome

Effective Medical Devices for Treating Tarsal Tunnel Syndrome

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Indications for shockwaves in veterinary medicine

Extracorporeal shock waves, a new non-surgical method to treat severe burns

EPAT Therapy Costs for Patients & Practices

EPAT Therapy Side Effects & Contraindications

Purple Heart Recipient Uses Innovative Technology to Treat Fellow Veterans

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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Pulsewave Therapy- Mechanism of Action and Clinical Indications

Pulsewave Therapy Explained: Mechanism of Action and Clinical Indications

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

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EPAT Shockwave Therapy Efficacy & Alternatives Explained

EPAT Shockwave Therapy Efficacy & Alternatives Explained

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Erectile Dysfunction and the Shocking Truth: Is Shockwave Therapy Effective

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy

Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

ESWT for Acute and Chronic Soft Tissue Wounds

ESWT minimizes ischemic tissue necrosis…

Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System

Effects of ESWT on glycosaminoglycan expression during bone healing

SoftWave’s New Leadership Team Accelerating Commercial Growth and Market Expansion

SoftWave vs Shockwave Technology Explained 

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Is SoftWave Therapy for Home Use?

SoftWave Therapy for Knees

SoftWave Therapy vs. Stem Wave & Acoustic Wave Devices for Knee Pain

Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

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Shockwave Therapy Of The Heart​

Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

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ISMST (International Society for Medical Shockwave Treatment)

ESWT for resident stress fractures in athletes.

EPAT Therapy for Plantar Fasciitis vs Alternatives

Chattanooga Shockwave Devices Compared- What Clinicians Should Evaluate

Chattanooga Shockwave Therapy Devices Compared

​STORZ MEDICAL’s NEUROLITH® receives CE approval – Transcranial Pulse Stimulation (TPS) on the central nervous system of patients with Alzheimer’s disease

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How Shockwave Therapy Compares to Cortisone Injections

How Shockwave Therapy Compares to Cortisone Injections

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

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Evaluation of extracorporeal shock wave therapy for osteoarthritis

Extracorporeal Shock Wave Therapy

Extracorporeal Shockwave Therapy for Arthritis Treatment

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Extracorporeal shockwave therapy (ESWT) ‒ First choice treatment of fracture non-unions

Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study

Exploring Regenerative Treatment for Knees After Failed Conservative Care

Regenerative Treatment for Knees That Fail Conservative Care

Tissue Activation and Regeneration in Sports Medicine and Bone Pathologies

Physical therapist guiding a woman through a leg exercise for sciatica pain.

Physical Therapy Treatment for Sciatica Pain: A Guide

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

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ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration

The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Project: SoftWaves to prevent opioid addiction and to help addicts in their recovery.

​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review

Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

MSC-exosome: A novel cell-free therapy for cutaneous regeneration

Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

Molecular changes in diabetics foot ulcers

Best Physical Therapy Devices Clinics Must Have

Best Physical Therapy Devices Clinics Must Have

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

Neck ache treatment essentials: massage pillow, essential oil, towel, exercise bands, and relaxation guide.

Neck Ache Treatment: 7 Safe Ways to Find Relief

Soft Wave Therapy: An Evidence-Aware Guide

Shockwave Therapy for Achilles Tendonitis

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Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

​The biologic effects of SoftWaves and rationale for spine and brain therapy

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Traditional Reimbursement vs Hybrid Practice for Shockwave Providers

​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

Macrophage migration induces angiogenesis

Alternatives to Cortisone Shots for Joint Pain Relief

Alternatives to Cortisone Shots for Joint Pain Relief

Veterinary wound care case study

Shock wave therapy alone has no impact on cancer growth

The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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Effects of Extracorporeal Shockwave Therapy on Patients with Chronic Low Back Pain and Their Dynamic Balance Ability

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Scientific Reports – Gene transfection by shock waves

Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

Treatment of scaphoid waist nonunion

Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

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Expanding Non-Surgical Options in Podiatry Clinics

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Heart Regeneration becomes Reality!

Three-time Super Bowl Champ RandyCross Finds Pain Relief With InnovativeTherapy from SoftWave TRT

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Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

How Does Piezoelectric Shockwave Compare to Electrohydraulic Shockwave for Clinical Use?

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Cleveland Clinic – Low Intensity Shockwaves In Urology

Symptomatic treatment of unresponsive wakefulness syndrome with transcranial focused extracorporeal shock waves

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CM Shockwave Before And After Use

Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures

Analysis of extracorporeal shock wave therapy for Peyronie’s disease

Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis

What Is EPAT Therapy & How Does It Work?

Is Shockwave Therapy Painful? What Practice Owners Should Tell Patients

Shockwave therapy in stress fractures

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

International Society for Medical Shockwave Treatment- ESWT BASIC PHYSICAL PRINCIPLES

Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

What Doctors Should Know About Storz Medical Shockwave

Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures

The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Low–Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

Best Treatment for Tennis Elbow Relief

Extracorporeal shock wave therapy: clinical applications and regulation

Zapping chronic tendon pain

Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shock wave therapy device

Shock waves promote spinal cord repair via TLR3

Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Chattanooga Intelect Shockwave Machine- Evidence, Mechanisms, and Clinical Context

Chattanooga Intelect Shockwave Machine: Efficacy & Alternatives

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Do Gymna Shockmaster Machines Work for Patients?

Do Gymna Shockmaster Machines Work for Patients?

“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

Stem cells pose risk, offer promise

How Does Shockwave Therapy Work?

Linear Shockwave Therapy in Clinical Practice- Evidence and Mechanisms

Linear Shockwave Therapy Mechanisms and Efficacy Explained

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

StemWave Machine: Cost, Reviews & Alternatives for Practice Owners

​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

Sports medicine practitioners embrace benefits of extracorporeal shock wave therapy

MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

Three-Time Super Bowl Champion Randy Cross Discovers Pain Relief with SoftWave Therapy

​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

​Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Spark Wave® Therapy Improves Cardiac Function

How Shockwave Therapy Breaks Down Scar Tissue

Extracorporeal Shock Wave Therapy: Current Evidence

EmFocus Shockwave Therapy- Features, Benefits, and Drawbacks

EmFocus Shockwave Therapy: Features, Benefits, and Drawbacks

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

Limited shock wave therapy vs sham treatment in men with Peyronie’s disease: results of a prospective randomized controlled double-blind trial

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

Shockwave Therapy vs. Laser Therapy: What Providers Need to Know

Shock wave treatment after hindlimb ischemia results in increased perfusion and M2 macrophage presence

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

Fully healed, Ordonez flourished for Tigers using ESWT

Pickleball Star Riley Newman Speeds Recovery With SoftWave Therapy

Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

ESWT in skin & aesthetic indications

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

Government Sales

Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

MTS Spark WaveTM Technology and its mechanism of action in wound management

Test12343

Comparing Shockwave Technologies for Treating Diabetic Foot Ulcers

Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment

Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Extracorporeal shockwave: mechanisms of action and physiological aspects…

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

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Shock wave therapy cost comparison with money and joint pain symbols on a balance scale.

How Much Shock Wave Therapy Costs: Price Guide

Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

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Low-energy Extracorporeal Shock Wave Therapy (ESWT) on secondary fibrolymphedema

SoftWave Therapy Averts Amputation for Former College Football Coach

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Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy

Pilot Trial, First Report Worldwide for Unfocused SoftWave® Therapy (uESWT) for the Treatment of Testicles to Improve Testicular Size and Function

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

What Is HydroWave Therapy? Mechanism, Applications, and Clinical Context

What Is HydroWave Therapy? How It Works, Clinical Uses, and Evidence

Analysis of treatment protocols: application of ESWT for wound healing disorders

Alternatives to Back Surgery Doctors Should Consider

Alternatives to Back Surgery Doctors Should Consider

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ESWT Therapy for Treatment of Keloid Scars

Low-intensity extracorporeal shock wave therapy for erectile dysfunction after radical prostatectomy

Cellular mechanotransduction: putting all the pieces together again

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Low-Intensity Shockwave Therapy May Be Beneficial for Women With Provoked Vestibulodynia

Non-Surgical Alternatives for Degenerative Disc Disease Treatment

Non-Surgical Treatment Options for Degenerative Disc Disease

Is surgery the only option for bone-on-bone?

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Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

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Shock wave therapy for systemic sclerosis

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How Li-ESWT Works for Patients With ED & Other Indications

Equine extracorporeal shock wave therapy

The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

SoftWave TRT vs Storz Shockwave Machines Compared

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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