SoftWave Research

Newest Research

The Use of Shock Waves in Peripheral Nerve Regeneration:New Perspectives?

Low-energy extracorporeal shock wave treatment (ESWT) is a relatively new therapeutic tool that is widely...
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​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

Treatment can be used alone or in combination with other therapies. Both young, athletic dogs...
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Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

This RCT investigated the effect of non-invasive extracorporeal shockwaves on tooth mobility in orthodontic patients...
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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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The Applied Mechanical Vibration as Extracorporeal Shock Wave

Maria Cristina D’Agostino, Simona Maria Carmignano, and Andrea Saggini Click here to read more.
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Shockwave treatment enhances cell proliferation and improves wound healing by ATP release coupled extracellular signal-regulated kinase (ERK) activation

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Extracorporeal Shock Wave Therapy: Current Evidence

The aim of this article is to provide a concise review of the basic science...
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Shock Waves Reach Dental Implantology (Spanish)

Lithotripsy or Shock Wave Therapy is proving to be an effective non-invasive treatment to regenerate...
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OrthoGold 100TM

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Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

This study investigated the plasma protein expression in the extracorporeal shock wave therapy group and...
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Orthopedic Protocol Manual

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Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

Tepeöylü et al.Journal of Tissue Engineering and Regenerative Medicine, 12(1), e486–e494. https://doi.org/10.1002/term.2317.2018 Click here to read...
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Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

The purpose of this meta-analysis was to assess the effects of extracorporeal shock wave therapy...
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​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

In this prospective design study the effects of low-energy partially focusedextracorporeal generated shock waves (ESW)...
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Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model

Qui et al.The Journal of Sexual Medicine, 10(3), 738–46. https://doi.org/10.1111/jsm.12024. Click here to read more.
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​ShockWave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation...
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Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy

Extracorporeal shockwave therapy (ESWT) is used in a number of indications in the medical field....
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The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

Rani S, Ritter T – Wound healing is a complex process and often delayed in patients with...
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Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

We prospectively studied extracorporeal shock wave therapy (ESWT) for calcific tendinitis of the shoulder in...
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Shock wave therapy for systemic sclerosis

We studied the effects of ESWT in 8 SSc female patients who received 4 consecutive...
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Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly...
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Intro to Treatment

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Patient Consent Form (Spanish)

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Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Nägele et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells

Rohringer et al. PLoS ONE, 9(12). https://doi.org/10.1371/journal.pone.0114806. Click here to read more.
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Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis

Carlotta Scarpa, MD, PhD, Vincenzo Vindigni, MD, PhD, and Franco Bassetto, MD Acoustic waves are mechanical waves...
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Prof. M. Kravchik. Focused shockwave therapy in the treatment of the spine. Oxford, UK Non-invasive treatment of herniated discs by focused shock wave therapy

 (​Non-invasive treatment of herniated discs by focused shockwave therapy) – In orthopedic practice meets a number...
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Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

d’Agostino MC., Sukubo NG., Tibalt W., Respizzi S., Locati M.,Int J Surg. 2015 Dec; 1-72015 Click...
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FDA Devices and Indications

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​​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

Chronic muscle pain syndrome is one of the main causes of musculoskeletal pathologies requiring treatment....
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Minimally invasive treatment of Peyronie’s disease: evidence-based progress

Department of Urology, Eastern Virginia Medical School, Norfolk, VA, *Division of Urologic Surgery, University of...
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Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions

Predictive models permitting individualized prognostication for patients with fracture nonunion are lacking. The objective of...
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Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Holfeld J., Zimpfer D., Stojadinvic A., et al.J Tissue Eng Regen Med.  Click here to...
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Biological mechanism of shockwave in bone

Shockwave is a rapid, short duration acoustic wave that carries energy and can propagate through...
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Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Hausner t. et al.Experimental Neurology, 236(2), 363–370. https://doi.org/10.1016/j.expneurol.2012.04.019. Click here to read more.
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Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It...
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ESWT minimizes ischemic tissue necrosis…

Rainer Mittermayr, MD, Joachim Hartinger, Vlado Antonic, MS, Alexandra Meinl, PhD, Sabine Pfeifer, Alexander Stojadinovic,...
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In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells

Schuh et al.Cytotherapy, 16(12), 1666–1678. https://doi.org/10.1016/j.jcyt.2014.07.005. Click here to read more.
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Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model

Introduction—Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from...
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Doubts over heart stem-cell therapy

The cells are then injected back into the patient, to help repair damaged tissue. Original...
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Extracorporeal shockwave therapy induces alveolar bone regeneration

Sathishkumar S, Meka A, Dawson D et al.J dent Res. 2008 Jul;87 Click here to read...
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​Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

Low energy shock waves have been shown to induce angiogenesis, improve left ventricular ejection fraction...
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Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

Chronic muscle pain syndrome is one of the main causes of musculoskeletal pathologies requiring treatment....
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Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

Cell-based therapies with autologous adipose tissue–derived cells have shown great potential in several clinical studies...
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Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers

We report the case of a 78-year-old woman with a history of hypertension, deep vein...
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Macrophage migration induces angiogenesis in ischemic myocardium after direct epicardial shock wave treatment

Holfeld et al. Thorac. Cardiovasc. Surg. (2012). doi:10.1055/s-0031-1297858 Click here to read more.
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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ESWT for resident stress fractures in athletes.

Stress fractures are major concerns with athletes. It is sometimes difficult to repair, resulting in...
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Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

The current ‘‘gold standard’’ for treatment of chronic fracture nonunion in the metaphyseal-diaphyseal region of...
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Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

The objective of this study is to demonstrate the efficacy and safety of AWT(®), combining two different mechanical...
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Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model

Wu et al.Transl Androl Urol. 2018 Mar;7(Suppl 1):S7-S16. doi: 10.21037/tau.2017.12.36.2018 Click here to read more.
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Ultrasound Based Brain Stimulation

Ultrasound based brain stimulation techniques bay become a powerful new technique to modulate the human...
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The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

Shockwave therapy was originally developed to disintegrate urinary stones 4 decades ago1 . Since then,...
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ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration

Hercher et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury

Thomas A Davis, Alexander Stojadinovic, Khairul Anam, Mihret Amare, Shruti Naik, George E Peoples, Douglas...
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Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

(Yousef Marwan, • Bashar Dahrab • Ali Esmaeel • Samir Abdulrazik Ibrahim • Jassim Al-Failakawi)...
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​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

Chronic muscle pain syndrome is one of the main causes of musculoskeletal pathologies requiring treatment....
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Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy

Scaphoid nonunion remains challenging for hand surgeons. Several treatment options are available such as: non-vascularized or...
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The Roll of Spark Waves in the Management of Chronic Wounds.

Antibiotic-resistant bacterial colonies often produce biofilms (a defensive mechanism that creates a physical protective barrier...
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Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although...
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Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Peyronie’s Disease (PD), and Sexual Rehabilitation After Radical Prostatectomy With Special Focus on Technical Aspects...
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Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

Christian Ottomann, MD, Bernd Hartmann, MD, Josh Tyler, MD, Heike Maier, MD, Richard Thiele, MD,Wolfgang...
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Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Dr. Slezak et al., Department of Physics Utah Valley University Orem, USA21th ISMST Congress in...
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Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: Implications for angiogenesis and vasculogenesis

Tepeköylü et al.Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2013.01.017. Click here to read more.
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Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

Schuh et al.Cytotherapy, 18(6), 760–770. https://doi.org/http://dx.doi.org/10.1016/j.jcyt.2016.03.002. Click here to read more.
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Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

Saggini R., Saggini A., Spagnoli A.M.Ultrasound in Med. & Biol. Vol. 42, No. 1, pp....
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Periodontal cytokines profile under orthodontic force and extracorporeal shock wave stimuli in a rat model

Hazan-Molina et al.Journal of Periodontal Research, 50(3), 389 -396.  https://doi.org/10.1111/jre.12218. Click here to read more.
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Can cellulite be treated with low-energy extracorporeal shock wave therapy?

The present study investigates the effects of low-energy defocused extracorporeal generated shock waves on collagen...
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Development of a prognostic naïve Bayesian classifier for successful treatment of nonunions

Stojadinovic A, Kyle Potter B, Eberhardt J, et al.J Bone Joint Surg Am. 2011; 93:187-194 Click...
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​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Rajendra Kashinath Shimpi, Ravi Jineshkumar Jain Department of Urology and Genito-Urinary Surgery, Ruby Hall Clinic,...
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Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury

(Swiss Paraplegic Centre Nottwil) – Spasticity is the most problematic self-reported secondary medical problem in patients...
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The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Extracorporeal shockwave therapy is a treatment modality, originally introduced into the clinic as lithotripsie, which...
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Evidence supporting extracorporeal shockwave therapy for acute and chronic soft tissue wounds

From Henry M. Jackson Foundation for Advancement in Military Medicine, Rockville, MD; Combat Wound Initiative...
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Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy

Hazan-Molina H., Reznick AZ., Kaufman H., Aizenbud D.Arch Oral Biol. 2013 Feb;58(2):142-50. Click here to read...
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Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite

Nowadays, the search for the ideal body is related to internal dissatisfactions that generate low...
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Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading...
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Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag​)

A prospective, randomized, double‐blinded, controlled pilot trial of 24 abdominoplasty patients revealed that preoperative application...
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Equine extracorporeal shock wave therapy

Extracorporeal shock wave therapy (ESWT) is an accepted form of treatment for chronic cases of...
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Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

Mesenchymal stem cells (MSC) possess the distinctive feature of homing in on and engrafting into...
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Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review

Extracorporeal shock wave therapy (ESWT), first described in the eighties for the treatment of urolithiasis,...
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Cervical Spine

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miR-19a-3p containing exosomes improve function of ischaemic myocardium upon shock wave therapy

As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous...
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Angiogenic response upon shock wave treatment of the ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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ESWT in skin & aesthetic indications

ESWT in skin graft epithelialization 3 days faster healing. Click here to read more.
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Quick User Guide

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Applicator Information : Focal Zones

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Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular...
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Shock wave application to cell cultures

Holfeld J., Tepeköylü C., et al.J Vis Exp. 2014 Apr 8;(86).2014 Click here to read...
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Extracorporeal shock wave treatment of capsular fibrosis after mammary augmentation

Preliminary results – (Caritas-Krankenhaus St. Josef, Klinik f ü r Plastische und Ä sthetische, Hand- und...
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Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

Mononuclear invasion of Langerhans islet and the ensuing insulitis triggers signal-transduction for the autoimmune mediated...
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Analysis of treatment protocols: application of ESWT for wound healing disorders

Shock waves are high-energy acoustic waves characterized by an initial rise of high pressure within...
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Shock waves promote spinal cord repair via TLR3

Spinal cord injury (SCI) remains a devastating condition with poor prognosis and very limited treatment...
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In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

Journal of Sexual Medicine (Guiting Lin MD PhD, Amanda B. Reed-Maldonado MD, Bohan Wang MD,...
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Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

Placebo controlled double-blinded, prospectively randomized clinical trial with 17 patients (11 verum, 5 placebo) for evaluation of cellulitetreatment with Acoustic Wave Therapy, (AWT(®))...
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Efficacy and safety of extracorporeal shock wave therapy for orthopedic conditions: a systematic review on studies listed in the PEDro database

Extracorporeal Shock Wave Research Unit, Department of Anatomy II, Ludwig-Maximilians-University of Munich, Pettenkoferstr.​ Extracorporeal shock wave...
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Radial Extracorporeal Shock Wave Therapy to Support Breathing In Case of Coronavirus Disease 2019 (COVID-19): A Case Report

Many patients with Coronavirus disease 2019 (COVID-19) suffer from shortness of breath and severe chest...
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Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

The purpose of this meta-analysis was to assess the effects of extracorporeal shock wave therapy...
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Instructions for Use

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Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

Extracorporeal shock wave therapy has been used in various clinical conditions as a result of...
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​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

Tibial non-unions are common cause of demanding revision surgeries and are associated with a significant...
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Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

van der Jagt OP, Schaden W, van Schie H et al.Orthopaedic Research Society. 2008; Poster No....
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Wound Protocol Manual

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Tissue Activation and Regeneration in Sports Medicine and Bone Pathologies

he physical shaking of the tissue by the shock waves leads to a mechanotransduction; the...
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Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

MTS Medical – First comparative report for MTS/TRT UroGold, (unfocused shockwaves “SoftWaves” ) and Radial/Ballistic waves,...
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Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for...
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Cleveland Clinic – Low Intensity Shockwaves In Urology

Cleveland Clinic Daniel Shoskes, MD – As urologists, we have decades of experience with extracorporeal shockwave lithotripsy for...
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Molecular changes in diabetics foot ulcers

The Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College...
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Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

Hsu et al.J. Shoulder Elb. Surg. 17, 55–59 (2008). Click here to read more.
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Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Lobenwein et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...
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Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats

We hypothesized that combined treatment with extracorporeal shock wave and bone marrow-derived endothelial progenitor cells...
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Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping and localized fat

Systematic review. – Extracorporeal Shockwave Therapy – ESWT has had a wide use in rehabilitation, and...
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The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

A Systematic Scoping Review of Pre-Clinical Studies – Using Cochrane’s methodologic recommendations on scoping studies and...
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Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

Anna M Larking, Sophie Duport Institute of Neuropalliative Rehabilitation, Royal Hospital for Neuro-disability, Michael Clinton...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

Holfeld J.,Tepeköylü C., Blunder S., et al.PLoS One. 2014 Aug 5;9(8):e1039822014 Click here to read more.
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Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy

Luis Amengual-Peñafiel, María C. Jara-Sepúlveda, Leopoldo Parada-Pozas, Francisco Marchesani-Carrasco, Ricardo Cartes-Velásquez, Blas Galdames-Gutiérrez. Click here...
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Veterinary wound care case study

The following images are of dog bites wounds sustained by a foal approximately one week...
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​Doubts Over Heart Stem-Cell Therapy

The cells are then injected back into the patient, to help repair damaged tissue. Original...
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Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

PubMed (Urology Department, Sheba Medical Center, Ramat-Gan, Israel; Ruth and Bruce Rappaport Faculty of Medicine,...
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The Physics of Shock Wave Lithotripsy

Shock wave lithotripsy (SWL) was introduced in the 1980s for the treatment of urinary stones...
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Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Megan BruzanMegan The low-energy extracorporal shockwave is a scientifically approved method to activate respectively increase...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Holfeld J., Tepeköylü., et al.Cardiovasc Res. 2016 Feb 1;109(2):331-43. Click here to read more.
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Protocol Manual

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Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Urology Section, Department of Surgery, University of Catania, Catania, Department of Urology, University of Florence, Andrology...
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Acoustic wave therapy for cellulite, body shaping and fat reduction.

Hexsel D, Camozzato FO, Silva AF, Siega In this open-label, single-centre trial, 30 women presenting moderate or severe...
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TRT SoftWaves® – a new regenerative therapy for paraplegia

Extracorporeal softwave therapy (ESWT) is widely used in clinical practice. In addition to its original...
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Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model

Lue TF., Qiu X., et al.J Sex Med. 2012;10(3):738-746 Click here to read more.
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Extracorporeal shock wave therapy surpresses the early proinflammatory immune response to a severe cutaneous burn injury

Davis T, Stojadinovic A, Anam K, et al.Int Wound J. 2009; 6:11-21 Click here to read...
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Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

Since December, 2019, an outbreak of pneumonia caused by a novel coronavirus (SARS-CoV-2) has raised...
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In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

Ottomann C., Antonic V., Münch S., et al.J Bioengineer & Biomedical Sci 2015, 6:12015 Click here...
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​Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

Human bone marrow stromal cells (hBMSCs) bear tremendous clinical potential due to their immunomodulatory properties...
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Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Pishchalnikov et al.Journal of Endourology / Endourological Society, 27(5), 631–9. https://doi.org/10.1089/end.2012.0611. Click here to read more.
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First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

IRB study at Georgia Urology, Atlanta, USA – Since 2007 at least 250.000 ED patients have...
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Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

Cell-based therapies with autologous adipose tissue–derived cells have shown great potential in several clinical studies...
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Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

Ultrasound based brain stimulation techniques may become a powerful new technique to modulate the human...
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Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

Mittermayr R, Antonic V, Hartinger J et al .Wound Repair Regen. 2012 Jul;20(4):456-65 Click here to...
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Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

MTS Science 2016. Urogenital indications such as painful penile angulation, erection problems and / or chronic...
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Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

In a prospective clinical trial, ESWT was performed consecutively 4 times over two weeks in...
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Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Cyrill Slezak Beijing, May 24TH, 2019 Click here to read more.
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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shockwave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the...
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Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Erectile dysfunction is highly prevalent in type II diabetes mellitus.Low intensity extracorporeal shock wave therapy...
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Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

Schaden W, Mittermayr R.Jatros Orthopädie & Rheumatologie. 5/2011; 72-74 Click here to read more.
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The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial

(Shih-Feng Lin, Yi-Jen Chen, Hung-Pin Tu , Chia-Ling Lee, Ching-Lin Hsieh , Wen-Lan Wu ,...
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ESWT for retracting scars of the hand

Department of Medical Sciences, Oral and Biotechnology, ‘‘G. D’Annunzio’’ University, Chieti, Italy;  Department of Dermatology,...
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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

Gollmann-Tepeköylü et al.Journal of the American Heart Association. https://doi.org/10.1161/JAHA.118.0100252008 Click here to read more.
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Scientific Reports – Gene transfection by shock waves

Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids...
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Case Series of Weekly Low Intensity Shockwave Therapy for Erectile Dysfunction

Shoskes et al., Cleveland Clinic, United States 20th ISMST Congress in San Sebastian, Spain Abstract...
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Shock wave treatment of muscle stem cells – a new implementation for regeneration

Fuchs et al. 20th ISMST Congress in San Sebastian, Spain Abstract P29 Click here to...
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Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat—Systematic review

Extracorporeal Shockwave Therapy – ESWT has had a wide use in rehabilitation, and has presented...
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Mechano-transduction effect of shock waves in the treatment of lumbar facet joint pain:Comparative effectiveness evaluation

(Charles University in Prague, 2nd Faculty of Medicine, Department of Neurology, Prague, Czech Republic Center...
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A randomized, controlled clinical study to investigate the safety and efficacy of acoustic wave therapy in body contouring

The objective of this study was to determine the safety and efficacy of noninvasive lipolysis of excess adiposities overlying the lateral...
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​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

Tibial non-unions are common cause of demanding revision surgeries and are associated with a significant...
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Cellular mechanotransduction: putting all the pieces together again

Vascular Biology Program, Departments of Pathology and Surgery, Harvard Medical School and Children’s Hospital, Boston,...
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Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

Rainer Mittermayr, MD; Vlado Antonic, MS; Joachim Hartinger ; Hanna Kaufmann, MD ; Heinz Redl,...
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Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease – A new navigated focal brain therapy

Ultrasound-based brain stimulation techniques offer an exciting potential to modulate the human brain in a...
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Symptomatic treatment of unresponsive wakefulness syndrome with transcranial focused extracorporeal shock waves

(​H. Lohse-Busch, U. Reime and R. Falland Outpatient Department for Manual Medicine – Movement Disorder...
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Comprehensive Urology to Utilize New Shockwave Therapy Device: PulseWave

PRESS RELEASE PR Newswire 2018 – Comprehensive Urology Medical Group, one of the nation’s leading...
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Biologic Response

LL37 and shock waves

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​ShockWave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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​Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

Low energy shock waves have been shown to induce angiogenesis, improve left ventricular ejection fraction...
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Shockwave treatment enhances cell proliferation and improves wound healing by ATP release coupled extracellular signal-regulated kinase (ERK) activation

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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