Kenneth Craig Vincent, Wolfgang Schaden, Laupepa Aposetolo Karalus, Jacqueline Craig Huges, Daniel Poratt – The ‘Niche’ is not merely an anatomical grid, but rather a dynamic communications conduit, sensing & transmitting signals (ie. biomechanical, chemical etc.) relaying the status & requirements of the tissue to its ‘Regenerative Cell’ source the Satellite Cells. Negative alterations or disruptions to the niche often result in defective regenerations in nearly every stem cell compartment of the region or body.