(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus) – Shock wave therapy (SWT) reportedly improves ventricular function in ischemic heart failure. Angiogenesis and inflammation modulatory effects were described. However, the mechanism remains largely unknown. We hypothesized that SWT modulates inflammation via toll-like receptor 3 (TLR3) through the release of cytosolic RNA. SWT was applied to human umbilical vein endothelial cells (HUVECs) with 250 impulses, 0.08 mJ/mm2 and 3 Hz.