SoftWave Literature

Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...

Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Nägele et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

The effect of shock waves on in vitro cartilage development in silk scaffolds

Szwarc et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Lobenwein et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Shock wave therapy enhances neuronal sprouting and improves neuronal survival

An et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

In vitro extracorporeal shock wave treatment has beneficial effects on rat Schwann cell isolation and culture

Schuh et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

Graber et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Holfeld et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent

Fuchs et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Shock wave treatment for in vitro engineering applications

Weihs et al. 4th ISMST Basic Research Meeting in Vienna, Austria Click here to read...

Penile low intensity shock wave therapy for PDE5i non responders: A prospective, randomized, placebo-controlled study

Fundació Puigvert, Barcelona, Spain European Congress of Andrology, Rotterdam, Netherlands Click here to read more.

Penile low-intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic erectile dysfunction since 2-10 years: A prospective, randomized, placebo-controlled study

Vinay et al., Fundació Puigvert, Barcelona, Spain 20th ISMST Congress in San Sebastian, Spain Click...

Efficacy of extracorporeal shockwave therapy (ESWT) for male chronic pelvic pain syndrome: a phase III, randomized, double blind controlled with placebo study 

Ramon et al., Hospital Quiron Barcelona, Spain 20th ISMST Congress in San Sebastian, Spain.Poster Session...

Shock wave therapy for osteoinduction

Koolen et al. 20th ISMST Congress in San Sebastian, Spain Abstract P33 Click here to...

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial

Holfeld et al. 20th ISMST Congress in San Sebastian, Spain Abstract P30 Click here to...

Shock wave treatment of muscle stem cells – a new implementation for regeneration

Fuchs et al. 20th ISMST Congress in San Sebastian, Spain Abstract P29 Click here to...

Elucidating the molecular mechanisms underlying cardiac shock wave therapy

Swarc et al. 20th ISMST Congress in San Sebastian, Spain Abstract P28 Click here to...

ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration

Hercher et al.TERMIS World Congress 2018 in Kyoto, Japan Click here to read more.

Case Series of Low Intensity Shock Wave Therapy for Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Shoskes et al., Cleveland Clinic, United StatesAUA Congress in Lisbon, Portugal Click here to read...

Benefits of Unfocused Li-ESWT for Erectile Dysfunction and Nocturia

When health issues arise, it is crucial to know what treatment options are available and...

Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Dr. Slezak et al., Department of Physics Utah Valley University Orem, USA21th ISMST Congress in...

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

Schaden W, Thiele R, Kolpl C, et al.J Surg Res. 2007; 143:1-12 Click here to read...

Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

van der Jagt OP, Schaden W, van Schie H et al.Orthopaedic Research Society. 2008; Poster No....

Extracorporeal shockwave therapy induces alveolar bone regeneration

Sathishkumar S, Meka A, Dawson D et al.J dent Res. 2008 Jul;87 Click here to read...

Angiogenic response to extracorporeal shock wave treatment in murine skin isografts

Stojadinovic A, Elster E, Anam EA, et al.Angiogenesis. 2008; 11(4):369-380 Alexander Stojadinovic 1, Eric A Elster, Khairul Anam, Douglas Tadaki, Mihret...

Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis

Van der Jagt et al.Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society,...

Extracorporeal shock wave therapy surpresses the early proinflammatory immune response to a severe cutaneous burn injury

Davis T, Stojadinovic A, Anam K, et al.Int Wound J. 2009; 6:11-21 Click here to read...

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Zimpfer D, Aharinejad S, Holfeld J, et al.J Thorac Cardiovasc Surg. 2009; 137(4):963-970 Click here to...

The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

Wolff et al.Ultrasound Med Biol. 2011 Jul;37(7):1111-9. Click here to read more.

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Ottomann C, Hartmann B, Tyler j, et al.J Am Coll Surg. 2010; 211(3):361-7 Click here to...

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Zins et al.Angiogenesis, 13(4), 293–304. https://doi.org/10.1007/s10456-010-9186-9. Abstract Impaired wound healing is a persistent clinical problem which...

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

Schaden W, Mittermayr R.Jatros Orthopädie & Rheumatologie. 5/2011; 72-74 Click here to read more.

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

Mittermayer R, Hartinger J, Antonic V, et al.Ann Surg. 2011; 253(5):1024-32 Click here to read more.

Better lithotripsy on the horizon: an interview with James E. Lingeman, MD.

Yard DH.Renal & Urology News. 2011 Click here to read more.

Unfocused extracorporeal shock waves induce anabolic effects in rat bone

van der Jagt OP, Piscaer TM, Schaden W, et al.J Bone Joint Surg Am. 2011; 93(2):38-48...

Macrophage migration induces angiogenesis

Holfeld et al. Thorac. Cardiovasc. Surg. (2012). doi:10.1055/s-0031-1297858 Click here to read full article – Macrophage...

Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

Mittermayr R, Antonic V, Hartinger J et al .Wound Repair Regen. 2012 Jul;20(4):456-65 Click here to...

Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1)

Sansone V, D’Agostino MC, Bonora C, et al.Journal of Biological Regulators & Homeostatic Agents 2012; 26(1):29-37...

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Hausner t. et al.Experimental Neurology, 236(2), 363–370. https://doi.org/10.1016/j.expneurol.2012.04.019. Click here to read more.

Assessment of IL-1β and VEGF concentration in a rat model during orthodontic tooth movement and extracorporeal shock wave therapy

Hazan-Molina H., Reznick AZ., Kaufman H., Aizenbud D.Arch Oral Biol. 2013 Feb;58(2):142-50. Click here to read...

Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

Van der Jagt et al.Journal of Orthopaedic Research, 31(5), 768–775. https://doi.org/10.1002/jor.22258. Click here to read more.

Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Pishchalnikov et al.Journal of Endourology / Endourological Society, 27(5), 631–9. https://doi.org/10.1089/end.2012.0611. Click here to read more.

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: a single-center, randomized, placebo-controlled clinical trial.

Falkensammer et al.Am J Orthod Dentofacial Orthop. 2014 Oct;146(4):413-22. doi: 10.1016/j.ajodo.2014.06.008. Click here to read...

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Falkensammer et al.Clin Oral Investig. 2014 Dec;18(9):2187-92. doi: 10.1007/s00784-014-1199-0. Click here to read more.

Shock wave treatment enhances stemness and preserves multipotency

Schuh et al.Cytotherapy, 16(12), 1666–1678. https://doi.org/10.1016/j.jcyt.2014.07.005. Click here to read full article on In vitro extracorporeal...

Effectiveness of Extracorporeal Shock Wave Lithotripsy to treat Dystrophic Calcinosis Cutis

Delgado-Marquez et al.Actas Dermosifiliogr. 2015 Mar;106(2):140-3. doi: 10.1016/j.ad.2014.06.006. Click here to read more.

In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

Ottomann C., Antonic V., Münch S., et al.J Bioengineer & Biomedical Sci 2015, 6:12015 Click here...

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

d’Agostino MC., Sukubo NG., Tibalt W., Respizzi S., Locati M.,Int J Surg. 2015 Dec; 1-72015 Click...

Lithotripter outcomes in a community practice setting: Comparison of an electromagnetic and an electrohydraulic lithotripter

Bhojani et al.J. Urol. (2015). doi:10.1016/j.juro.2014.09.117. Click here to read more.

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Holfeld J., Zimpfer D., Stojadinvic A., et al.J Tissue Eng Regen Med. Click here to...

Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

Saggini R., Saggini A., Spagnoli A.M.Ultrasound in Med. & Biol. Vol. 42, No. 1, pp....

The Role of Extracorporeal Shock Wave Therapy and Manual Lymphatic Drainage in Chronic Ulcers Treatment

Saggini et al. Int J Pharma Sci Res 2016, 3: 119 Click here to read more.

The Concept of Spark Wave Therapy (Swt) Assisted Penile Augmentation

Dr. Mirza Niaz Zaman, Kharkiv National Medical University, UkraineJSexMed. May, 2017; e329–e3302016 Click here to read...

Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Onger et al.Med Oral Patol Oral Cir Bucal. 2017 Mar 1;22(2):e251-e257.2017 Click here to read...

Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy

Priglinger et al.Cytotherapy. 2017 Sep;19(9):1079-1095. doi: 10.1016/j.jcyt.2017.05.010. Epub 2017 July 19, 2017 Click here to read...

Optimization of screw fixation in rat bone with extracorporeal shock waves

Koolen et al.Journal of Orthopaedic Research. https://doi.org/10.1002/jor.23615. Click here to read more.

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Fleckenstein et al.Arch. Phys. Med. Rehabil. 98, 923–930 (2017). Click here to read more.

Shock wave treatment after hindlimb ischaemia results in increased perfusion and M2 macrophage presence

Tepeöylü et al.Journal of Tissue Engineering and Regenerative Medicine, 12(1), e486–e494. https://doi.org/10.1002/term.2317.2018 Click here to read...

Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

Antonic et al., 2018Wound medicine 20 (2018) 1-6https://doi.org/10.1016/j.wndm.2017.11.0012018 Click here to read more.

Treatment of scaphoid waist nonunion

Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or...

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

Feichtinger et al.Am J Sports Med. 2019 Jul;47(9):2158-2166.2019 Click here to read more.

MTS Science White Paper – Softwave – Pain Therapy

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MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

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MTS Spark Wave Publications – Science Telegram

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Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

Anna M Larking, Sophie Duport Institute of Neuropalliative Rehabilitation, Royal Hospital for Neuro-disability, Michael Clinton...

Extracorporeal shockwave treatment for chronic diabetic foot ulcers

Seventy-two patients with 72 chronic diabetic foot ulcers were randomly divided into two groups of...

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shockwave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the...

Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

This study investigated the plasma protein expression in the extracorporeal shock wave therapy group and...

Prophylactic Low-Energy Shock Wave Therapy Improves Wound Healing After Vein Harvesting for Coronary Artery Bypass Graft Surgery: A Prospective, Randomized Trial

Wound healing disorders after vein harvesting for coronary artery bypass graft surgery increase morbidity and...

Effects of Low-Energy Shockwave Therapy on the Erectile Function and Tissue of a Diabetic Rat Model

Introduction—Low-energy shockwave therapy (LESWT) has been shown to improve erectile function in patients suffering from...

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

MTS-Science Low-intensity extracorporeal shock wave therapy (LI-ESWT) is of great clinical interest for the treatment...

Treatment of stress urinary incontinence

To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress...

Shock waves induce angiogenesis via exosome release

Click here to read more.

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate...

Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

Accelerated tooth movement has been a topic of interest for orthodontic research recently. Surgically facilitated...

Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

This RCT investigated the effect of non-invasive extracorporeal shockwaves on tooth mobility in orthodontic patients...

Effect of Extracorporeal Shockwave Therapy (ESWT) on Pulpal Blood Flow After Orthodontic Treatment: A Randomized Clinical Trial

The effect of non-invasive extracorporeal shockwaves on pulpal blood flow in orthodontic patients who have...

Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

Extracorporeal shock wave therapy has been used in various clinical conditions as a result of...

The Influence of Shockwave Therapy on Orthodontic Tooth Movement Induced in the Rat

The application of orthodontic force evokes an inflammatory reaction resulting in tooth movement. Shockwave therapy...

Effects of Low-Energy Shock Waves on Oral Bacteria

The objective of the present study was to determine any antibacterial effect of ESWT on...

Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy

Christian Ottomann, MD,∗ Alexander Stojadinovic, MD, FACS, Philip T. Lavin, PhD, Francis H. Gannon, MD,...

Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

Shock waves have been shown to induce recruitment of intravenously injected endothelial progenitor cells to...

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading...

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

Mechanical stimulation of acute ischemic myocardium by shock wave therapy (SWT) is known to improve...

Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor...

Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions

Predictive models permitting individualized prognostication for patients with fracture nonunion are lacking. The objective of...

Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

Tibial non-unions are common cause of demanding revision surgeries and are associated with a significant...

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

The current ‘‘gold standard’’ for treatment of chronic fracture nonunion in the metaphyseal-diaphyseal region of...

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

Background-—Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular...

Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...

Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

As new approaches for peripheral nerve regeneration are sought, there is an increasing demand for...

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