Skin grafting is one of the most common treatment options for permanent replacement of lost skin and proven effective in burn patients. The procedure consists of transplantation of skin or artificial dermal replacements, and in some instances underlying tissues, harvested from one anatomical location to a different location. However the ischemic insult, due to nature of the procedure itself, on the graft tissue is the major problem for the graft integration and durability. By adding the increase in the number of severe full-thickness skin injuries both in civilian and military settings to the burn injuries, the need for efficient, safe, and cost-effective supplemental therapeutics is obvious to avoid graft failures, revision surgeries and expenses associated with care for these patients.