We report the case of a 78-year-old woman with a history of hypertension, deep vein thrombosis, valvular heart disease treated with coumarin, osteoporosis, and overlap syndrome. In addition, she had diagnostic findings consistent with systemic lupus erythematosus (pleuropericarditis, lupus erythematosus panniculitis, subacute cutaneous lupus erythematosus, malar rash, oral ulcers, arthritis, leukopenia and thrombocytopenia, meningitis, and positive tests for antinuclear antibodies and antiribonucleoprotein antibodies) as well as with scleroderma (sclerodactyly, severe Raynaud syndrome, esophageal disease, interstitial pulmonary disease, and a positive test for anticentromere antibodies).