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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Extracorporal SoftWave Treatment to Improve Nerve Regeneration

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low intensity softwave in use on arm on a table

What is Li-ESWT & How Does It Work?

​Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy

Indications for shockwaves in veterinary medicine

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review

Spark Wave® Therapy – a New Method for Peripheral Nerve Regeneration

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Minimally invasive treatment of Peyronie’s disease: evidence-based progress

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

SoftWave on Elbow

Radial Shockwave Therapy Benefits & Alternatives

Shockwave Therapy Helping Patients With Peripheral Artery Disease

Best Shockwave Therapy Machine For Providers

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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

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Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines: Cost, Efficacy, & Alternatives

​Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

​The biologic effects of SoftWaves and rationale for spine and brain therapy

IVSWT Water Bath V2.0 Manual

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

Spark Wave® Therapy Improves Cardiac Function

Extracorporeal shock wave therapy (ESWT) for wound healing : Technology, mechanisms, and clinical efficacy

The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

Biological mechanism of musculoskeletal shockwaves

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MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

The Applied Mechanical Vibration as Extracorporeal Shock Wave

The Effect of Different Doses of Extracorporeal Shock Waves on Experimental Model Mandibular Distraction

MTS Science White Paper – Softwave – Pain Therapy

MTS Spark Wave Publications – Science Telegram

Adhesive Capsulitis Management with Advanced Shockwave Therapy

SoftWave: Empowering Adhesive Capsulitis Management with Advanced Shockwave Therapy

Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Can cellulite be treated with low-energy extracorporeal shock wave therapy?

Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

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​Extracorporeal shock wave therapy: What? Why? Safety?

Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

SoftWave: Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

Extracorporeal shockwave therapy (ESWT) ‒ First choice treatment of fracture non-unions

Physical Rehabilitation Using Shockwave Therapy

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Alternatives to Cortisone Shots

Extracorporeal shock wave therapy relieved pain in patients with coccydynia: a report of two cases

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ESWT minimizes ischemic tissue necrosis…

Complementary effect of L-citrulline supplementation on SparkWave™ therapy-induced angiogenesis and regeneration

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

MTS Spark WaveTM Technology and its mechanism of action in wound management

Cellulite and Focused Extracorporeal Shockwave Therapy for Non-Invasive Body Contouring: A Randomized Trial

Effect of shock waves on macrophages

Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: A single-center, randomized, placebo-controlled clinical trial

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Equine extracorporeal shock wave therapy

​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

Extracorporeal shock wave therapy surpresses the early proinflammatory immune response to a severe cutaneous burn injury

Sports medicine practitioners embrace benefits of extracorporeal shock wave therapy

Analysis of extracorporeal shock wave therapy for Peyronie’s disease

​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Extracorporeal Shock Wave Treatment: An Emerging Treatment Modality For Retracting Scars of The Hands

Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis​

Extracorporeal shockwave therapy induces alveolar bone regeneration

Extracorporeal Shockwave Therapy for Arthritis Treatment

Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

Cellular mechanotransduction: putting all the pieces together again

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers

Low-Intensity Shockwave Therapy May Be Beneficial for Women With Provoked Vestibulodynia

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

SoftWave : Transforming Foot Pain Management with Advanced Shockwave Therapy

Biological Principles – Mechanotransduction

Natural Remedies for Tendonitis

The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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ESWT for resident stress fractures in athletes.

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Extracorporeal shock wave therapy: clinical applications and regulation

Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

Effect of Extracorporeal Shockwave Therapy (ESWT) on Pulpal Blood Flow After Orthodontic Treatment: A Randomized Clinical Trial

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Shock Waves Reach Dental Implantology (Spanish)

Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

AUVA letter‒ Successful treatment of delayed and non-union fractures

10 Natural Ways to Find Pain Relief

Athletic therapy (Mts-Science)

Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

TISSUE REGENERATION TECHNOLOGIES, LLC Establishment Registration & Device Listing

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

Shock wave treatment after hindlimb ischemia results in increased perfusion and M2 macrophage presence

​Exosomes and Cardiovascular Protection

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears

Ultrasound Based Brain Stimulation

A prospective, randomized, controlled, single centre trial to assess the efficacy and safety of radial extracorporeal shockwave therapy in patients with chronic non-specific low back pain

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Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

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Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses. – PubMed – NCBI

Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Extracorporeal Magnetic Transduction Therapy Explained

Extracorporeal Magnetic Transduction Therapy Explained

Low-energy Extracorporeal Shock Wave Therapy (ESWT) on secondary fibrolymphedema

Shockwave Therapy: Does it Hurt?

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Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

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Shock waves promote spinal cord repair via TLR32

Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

SoftWave: Pioneering Shoulder Pain Relief with Advanced Shockwave Therapy

The Physics of Shock Wave Lithotripsy

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

ISMST (International Society for Medical Shockwave Treatment)

​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

ISSWSH Abstract

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

Focused vs Radial Shockwave Therapy Machines Explained 

The Biologic Effects of SoftWaves™and Rationale for Spine and Brain Therapy

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Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Prophylactic Low-Energy Shock Wave Therapy Improves Wound Healing After Vein Harvesting for Coronary Artery Bypass Graft Surgery: A Prospective, Randomized Trial

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Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag​)

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial

Urological Times Cover – Scroll to Page 18 – 19

Alternative Treatment using Shockwave for Erectile Dysfunction

Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

​Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors

Shock wave therapy for osteoinduction

Acoustic Wave Therapy vs Shockwave Therapy

Extracorporeal shock wave treatment of capsular fibrosis after mammary augmentation

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

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​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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Extracorporeal Shock Wave Therapy: Current Evidence

Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

Evaluation of extracorporeal shock wave therapy for osteoarthritis

EPAT Therapy Side Effects & Contraindications

Is surgery the only option for bone-on-bone?

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SoftWave Tissue Regeneration Technologies Receives FDA Clearance for Blood Circulation Increase, Minor Aches and Pains Relief and Connective Tissue Activation

In vitro characterization and simulation of shockwaves by optical phase contrast imaging, computational modeling and acoustic measurement.

Optimization of screw fixation in rat bone with extracorporeal shock waves

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

Extracorporeal shockwave therapy for treatment of keloid scars

Heart Regeneration becomes Reality!

Extracorporeal shockwave: mechanisms of action and physiological aspects…

DIGEST Guidelines for Extracorporeal Shock Wave Therapy

Using Sound to Battle Opioid Crisis

Treatment of scaphoid waist nonunion by one, two headless compression screws or plate with or without additional extracorporeal shockwave therapy

Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study

Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

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Lohse – Busch ISMST Presentation

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

Analysis of treatment protocols: application of ESWT for wound healing disorders

Effects of Low-Energy Shock Waves on Oral Bacteria

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ESWT for retracting scars of the hand

EPAT Shockwave Therapy Efficacy & Alternatives Explained

EPAT Shockwave Therapy Efficacy & Alternatives Explained

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Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial

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Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

Shock waves promote spinal cord repair via TLR3

Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin Angiotensin System

The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

Benefits of Spark Wave Therapy in neuronal regeneration

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Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Extracorporeal Shock Wave Therapy

Peripheral Nerve Regeneration

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)

Hip Pain Management with Advanced Shockwave Therapy

SoftWave: Revolutionizing Hip Pain Management with Advanced Shockwave Therapy

Shockwave Therapy Of The Heart​

Dr. Lohse Bush, first brain treatments

​Extracorporeal shock wave therapy in periodontics: A new paradigm

Stem cells pose risk, offer promise

Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

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Radial Extracorporeal Shock Wave Therapy to Support Breathing In Case of Coronavirus Disease 2019 (COVID-19): A Case Report

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment

FUNDAMENTALS OF VIBRATION-INDUCED, CELL POLARIZING TREATMENT MALIGNER DISEASES

Extracorporeal shockwave therapy shows site-specific effects in osteoarthritis of the knee in rats

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

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Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1)

Shockwave therapy in stress fractures

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

ESWT in skin & aesthetic indications

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

​Antibacterial effects of extracorporeal shock waves

Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

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​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

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Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

COVID-19 pneumonia: different respiratory treatment for different phenotypes?

Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

SoftWave vs Shockwave Technology Explained 

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SDSM Spine pain protocol

Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Latest Basic Research Abstracts

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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